TOFE human-B-cell-line-based adsorption-inhibition assay to detect HCV neutralizing antibodies

M. B. Valli; L. Bertolini; A. Manzin; M. Clementi; G. Carloni

doi:10.1016/S0923-2516(99)89015-3

TOFE human-B-cell-line-based adsorption-inhibition assay to detect HCV neutralizing antibodies

M. B. Valli, L. Bertolini, A. Manzin, M. Clementi, G. Carloni

Research output: Contribution to journal › Article › peer-review

Abstract

We previously demonstrated that the human lymphoblastoid B-cell line (LCL) TOFE, derived from normal human bone marrow, is permissive to HCV infection. In this report we developed an in vitro HCV adsorption-inhibition assay based on TOFE cells, to reveal the presence of neutralizing antibodies in sera from acutely infected patients.

Original language	English
Pages (from-to)	331-333
Number of pages	3
Journal	Research in Virology
Volume	149
Issue number	5
DOIs	https://doi.org/10.1016/S0923-2516(99)89015-3
Publication status	Published - Sept 1998

Keywords

B-cell line
HCV
Neutralizing antibodies
PCR
TOFE cells

ASJC Scopus subject areas

Virology
Immunology

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10.1016/S0923-2516(99)89015-3

Cite this

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title = "TOFE human-B-cell-line-based adsorption-inhibition assay to detect HCV neutralizing antibodies",

abstract = "We previously demonstrated that the human lymphoblastoid B-cell line (LCL) TOFE, derived from normal human bone marrow, is permissive to HCV infection. In this report we developed an in vitro HCV adsorption-inhibition assay based on TOFE cells, to reveal the presence of neutralizing antibodies in sera from acutely infected patients.",

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author = "Valli, {M. B.} and L. Bertolini and A. Manzin and M. Clementi and G. Carloni",

year = "1998",

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AU - Valli, M. B.

AU - Bertolini, L.

AU - Manzin, A.

AU - Clementi, M.

AU - Carloni, G.

PY - 1998/9

Y1 - 1998/9

N2 - We previously demonstrated that the human lymphoblastoid B-cell line (LCL) TOFE, derived from normal human bone marrow, is permissive to HCV infection. In this report we developed an in vitro HCV adsorption-inhibition assay based on TOFE cells, to reveal the presence of neutralizing antibodies in sera from acutely infected patients.

AB - We previously demonstrated that the human lymphoblastoid B-cell line (LCL) TOFE, derived from normal human bone marrow, is permissive to HCV infection. In this report we developed an in vitro HCV adsorption-inhibition assay based on TOFE cells, to reveal the presence of neutralizing antibodies in sera from acutely infected patients.

KW - B-cell line

KW - HCV

KW - Neutralizing antibodies

KW - PCR

KW - TOFE cells

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U2 - 10.1016/S0923-2516(99)89015-3

DO - 10.1016/S0923-2516(99)89015-3

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JO - Research in Virology

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IS - 5

ER -

TOFE human-B-cell-line-based adsorption-inhibition assay to detect HCV neutralizing antibodies

Abstract

Keywords

ASJC Scopus subject areas

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