TY - JOUR
T1 - Tissue with high intelligence quotient
T2 - Adipose-derived stem cells in neural regeneration
AU - Chaldakov, George N.
AU - Fiore, Marco
AU - Tonchev, Anton B.
AU - Hristova, Mariyana G.
AU - Nikolova, Vesselka
AU - Aloe, Luigi
PY - 2009/12
Y1 - 2009/12
N2 - The aim of the present review is to highlight the possible neuroregenerative potential of adipose-derived stem cells. The key property of stem cells is plasticity including self-renewal, multilineage differentiation, and migration, whereas the required property is transplantability. For a long time, embryonic stem cells were thought to be the only source of pluripotency, a dogma that has been challenged during the last decade. Today, an alternative option might be adipose-derived stem cells, as easily accessible, ethical and autologous cellular source. Recent knowledge of adipobiology increasingly recognizes that adipose tissue is the major endo- and paracrine organ of the human body. Likewise, numerous neuropetides, neurotrophic factors, neurotransmitters, hypothalamic and steroid hormones and their receptors are shared by adipose tissue and brain. Accordingly, the regenerative potential of neuroprotective factor-secreting adipose-derived stem cells is outlined. Whether the possible benefits of adipose stem cell-based therapy may be mediated via cell transdifferentiation and/or paracrine mechanisms remains to further be evaluated.
AB - The aim of the present review is to highlight the possible neuroregenerative potential of adipose-derived stem cells. The key property of stem cells is plasticity including self-renewal, multilineage differentiation, and migration, whereas the required property is transplantability. For a long time, embryonic stem cells were thought to be the only source of pluripotency, a dogma that has been challenged during the last decade. Today, an alternative option might be adipose-derived stem cells, as easily accessible, ethical and autologous cellular source. Recent knowledge of adipobiology increasingly recognizes that adipose tissue is the major endo- and paracrine organ of the human body. Likewise, numerous neuropetides, neurotrophic factors, neurotransmitters, hypothalamic and steroid hormones and their receptors are shared by adipose tissue and brain. Accordingly, the regenerative potential of neuroprotective factor-secreting adipose-derived stem cells is outlined. Whether the possible benefits of adipose stem cell-based therapy may be mediated via cell transdifferentiation and/or paracrine mechanisms remains to further be evaluated.
KW - Adipose tissue
KW - Neurodegeneration
KW - Neurotrophic factors
KW - Regeneration
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=77949504137&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949504137&partnerID=8YFLogxK
U2 - 10.3969/j.issn.1673-5374.2009.12.026
DO - 10.3969/j.issn.1673-5374.2009.12.026
M3 - Article
AN - SCOPUS:77949504137
SN - 1673-5374
VL - 4
SP - 1116
EP - 1120
JO - Neural Regeneration Research
JF - Neural Regeneration Research
IS - 12
ER -