TY - JOUR
T1 - Tissue factor in human coronary atherosclerotic plaques
AU - Ardissino, Diego
AU - Merlini, Piera Angelica
AU - Arlens, Robert
AU - Coppola, Raffaella
AU - Bramucci, Ezio
AU - Lucreziotti, Stefano
AU - Repetto, Alessandra
AU - Fetiveau, Raffaela
AU - Mannuccio Mannucci, Pier
PY - 2000/2/15
Y1 - 2000/2/15
N2 - The rupture or fissuring of a coronary atherosclerotic plaque and subsequent thrombosis is considered the key event in the pathogenesis of unstable angina and myocardial infarction. Although plaque disruption frequently occurs during the evolution of atherosclerosis, only a minority of ruptured plaques develop thrombosis. The content and procoagulant activity of tissue factor in human coronary atherosclerotic plaques varies widely, and different studies confirm that it is higher in the plaques extracted from patients with unstable angina, myocardial infarction or histologic/angiographic evidence of coronary thrombosis than in those taken from patients with stable angina or uncomplicated coronary lesions. Variations in tissue factor content and activity may be responsible for the different thrombotic responses to human coronary atherosclerotic plaque rupture. (C) 2000 Published by Elsevier Science B.V.
AB - The rupture or fissuring of a coronary atherosclerotic plaque and subsequent thrombosis is considered the key event in the pathogenesis of unstable angina and myocardial infarction. Although plaque disruption frequently occurs during the evolution of atherosclerosis, only a minority of ruptured plaques develop thrombosis. The content and procoagulant activity of tissue factor in human coronary atherosclerotic plaques varies widely, and different studies confirm that it is higher in the plaques extracted from patients with unstable angina, myocardial infarction or histologic/angiographic evidence of coronary thrombosis than in those taken from patients with stable angina or uncomplicated coronary lesions. Variations in tissue factor content and activity may be responsible for the different thrombotic responses to human coronary atherosclerotic plaque rupture. (C) 2000 Published by Elsevier Science B.V.
KW - Coronary thrombosis
KW - Myocardial infarction
KW - Tissue factor
KW - Unstable angina
UR - http://www.scopus.com/inward/record.url?scp=0034651824&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034651824&partnerID=8YFLogxK
U2 - 10.1016/S0009-8981(99)00231-4
DO - 10.1016/S0009-8981(99)00231-4
M3 - Article
C2 - 10675726
AN - SCOPUS:0034651824
SN - 0009-8981
VL - 291
SP - 235
EP - 240
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 2
ER -