Tissue factor in human coronary atherosclerotic plaques

Diego Ardissino, Piera Angelica Merlini, Robert Arlens, Raffaella Coppola, Ezio Bramucci, Stefano Lucreziotti, Alessandra Repetto, Raffaela Fetiveau, Pier Mannuccio Mannucci

Research output: Contribution to journalArticlepeer-review


The rupture or fissuring of a coronary atherosclerotic plaque and subsequent thrombosis is considered the key event in the pathogenesis of unstable angina and myocardial infarction. Although plaque disruption frequently occurs during the evolution of atherosclerosis, only a minority of ruptured plaques develop thrombosis. The content and procoagulant activity of tissue factor in human coronary atherosclerotic plaques varies widely, and different studies confirm that it is higher in the plaques extracted from patients with unstable angina, myocardial infarction or histologic/angiographic evidence of coronary thrombosis than in those taken from patients with stable angina or uncomplicated coronary lesions. Variations in tissue factor content and activity may be responsible for the different thrombotic responses to human coronary atherosclerotic plaque rupture. (C) 2000 Published by Elsevier Science B.V.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalClinica Chimica Acta
Issue number2
Publication statusPublished - Feb 15 2000


  • Coronary thrombosis
  • Myocardial infarction
  • Tissue factor
  • Unstable angina

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry


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