Time to re-consider the meaning of BRAF V600E mutation in papillary thyroid carcinoma

Greta Gandolfi, Valentina Sancisi, Simonetta Piana, Alessia Ciarrocchi

Research output: Contribution to journalArticlepeer-review


The BRAF V600E mutation, resulting from the BRAFT1799A transversion, is the most common genetic mutation in papillary thyroid carcinoma (PTC), with a mean frequency close to 50% among all cases. A large number of studies in the past decade have tried to dissect the relevance and the function of the V600E mutation in controlling oncogenesis and progression of thyroid cancer. However, several works published in the latest years have provided new evidence, in partial conflict with the previous knowledge, suggesting the need of reconsidering the meaning of the BRAF V600E mutation in PTC. In this work, we attempt to discuss some of the most recent molecular, preclinical and clinical evidence to construct a more exhaustive model of function for the BRAF V600E in development, progression and therapeutic approach of thyroid cancer.

Original languageEnglish
Pages (from-to)1001-1011
Number of pages11
JournalInternational Journal of Cancer
Issue number5
Publication statusPublished - Sept 1 2015


  • BRAF
  • molecular marker
  • papillary thyroid carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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