Thyroid hormone-induced up-regulation of β1- and β2-adrenergic receptors during aging

C. Viticchi, A. Basso, A. Zaia, L. Piantanelli

Research output: Contribution to journalArticlepeer-review


Strong experimental evidence suggests that thyroid hormones influence β-adrenoceptor regulation. The question arises whether in tissues like mouse brain cortex bearing both β1- and β2-subpopulations, these receptor subtypes may be regulated independently, as demonstrated after some drug stimulations. An eventual influence of aging on triiodothyronine (T3)-induced subpopulation response is also worth studying, because of the decrease of receptor density in old animals observed only in the β1-type. These points have been addressed in the present paper, performing experiments on young and old mice stimulated with a single injection of T3. The response has been assayed as rapidly as 15 min after T3 treatment. Results on untreated control mice confirm previous findings showing that the decrease of receptor density is in charge only of the β1-subtype. T3 stimulation induces up-regulation of both β1- and β2-adrenoceptors in young animals. The response shows no impairment with aging, as in both receptor subtypes a significant increase can be demonstrate. Due to the very short time of response, and unmasking mechanism can be hypothesized for receptor up-regulation, though an increase of protein synthesis cannot be excluded.

Original languageEnglish
Pages (from-to)367-374
Number of pages8
JournalArchives of Gerontology and Geriatrics
Issue numberSUPPL. 1
Publication statusPublished - 1992


  • aging of mouse
  • brain cortex
  • receptor subpopulations
  • thyroid hormones
  • β-adrenoceptor regulation

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Gerontology
  • Health(social science)
  • Medicine(all)


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