Thrombophilia and fetal germinal matrix-intraventricular hemorrhage: Does it matter?

L. A. Ramenghi, M. Fumagalli, A. Righini, F. Triulzi, A. Kustermann, F. Mosca

Research output: Contribution to journalArticlepeer-review


Germinal matrix-intraventricular hemorrhage (GMH-IVH) in the fetus is very rare and the role of thrombophilia in its pathogenesis is unclear. We report on the prenatal diagnosis by magnetic resonance imaging of GMH-IVH in a 24-week fetus. The newborn presented posthemorrhagic ventriculomegaly and was found to be heterozygous for two thrombophilic patterns, factor V Leiden and methylenetetrahydrofolate reductase mutation. The combination of this hypercoagulable state and prenatal GMH-IVH is discussed together with the opportunity of testing these infants for thrombophilia.

Original languageEnglish
Pages (from-to)574-576
Number of pages3
JournalUltrasound in Obstetrics and Gynecology
Issue number5
Publication statusPublished - Oct 2005


  • Factor V leiden
  • Fetal hemorrhage
  • Thrombophilia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Radiology Nuclear Medicine and imaging
  • Reproductive Medicine
  • Acoustics and Ultrasonics
  • Radiological and Ultrasound Technology


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