Thoracic stop-flow perfusion for refractory lymphoma: A phase I-Il evaluation trial

Cristina Ruscitti, Stefano Guadagni, Filippo Russo, Giancarlo Palumbo, Giammaria Fiorentini, Andrea Mambrini, Maurizio Cantore, Evangelos Kanavos, Antonio Pinto, Gianfranco Amicucci

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Background: Management of patients with heavily pretreated malignant lymphoma failing front-line treatment and salvage high-dose chemotherapy and autologous peripheral stem cell rescue is problematic. A phase I-Il evaluation trial was conducted to evaluate thoracic stop-flow perfusion. Patients and Methods: nine refractory patients were enrolled in the study. The schedule of thoracic stop-flow perfusion was based on cisplatin (100 mg/m2) and melphalan (25 mglm2). Meiphalan pharmacokinetic analyses were performed. All patients received hemofiltration during each procedure. Results: Overall 18 cycles of perfusional chemotherapy were administerd. During the procedures there were no technical, hemodynamic, or vascular complications, and no deaths occurred during surgery. Hematological and non-hematological toxicity was mild in relation to the use of hemofiltration during the procedures. All 9 patients responded favoura bly to stop-flow therapy. We observed 5 CR and 4 PR. Four out of five patients in CR relapsed. Three out of these four died of progressive disease after a response duration of 9, 7 and 7 months, respectively. One patient had a duration of CR of 10 months before relapse. He attained a new PR (+ 3 months). The remaining complete responder is still in remission aftre 37% months. The 4 patients in PR progressed and died after a response duration of 4, 6, 2 and 1 month, respectively. To date, 8 Out of 9 patients have died and one is still alive. Conclusion: Thoracic stop-flow perfusion seems very active in this kind of patient.

Original languageEnglish
Pages (from-to)447-458
Number of pages12
JournalIn Vivo
Issue number3
Publication statusPublished - May 2009


  • lymphoma
  • melphalan
  • Perfusion
  • pharmacokinetic
  • stop-flow

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology


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