Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep3B and HepG2 cells

Jeffrey Kerns; Sriram Naganathan; Paul Dowd; Frances M. Finn; Brian Carr

doi:10.1006/bioo.1995.1008

Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep3B and HepG2 cells

Jeffrey Kerns, Sriram Naganathan, Paul Dowd, Frances M. Finn, Brian Carr

Ente Ospedaliero Specializzato in Gastroenterologia "Saverio de Bellis"

Research output: Contribution to journal › Article › peer-review

Abstract

A new hypothesis regarding the effect of vitamin K₃ on hepatoma cell growth is presented. In brief, exploration of cell growth activity has been identified with the action of p34(cdc2) kinase and its associated protein tyrosine phosphatase. After exploring a series of substituted derivatives of vitamin K and vitamin K₃ oxide, we suggest a mechanism involving alkylation at the active-site cysteine for the inhibition of the protein tyrosine phosphatase which controls the activity of the p34(cdc2) kinase.

Original language	English
Pages (from-to)	101-108
Number of pages	8
Journal	Bioorganic Chemistry
Volume	23
Issue number	2
DOIs	https://doi.org/10.1006/bioo.1995.1008
Publication status	Published - 1995

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery

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10.1006/bioo.1995.1008

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abstract = "A new hypothesis regarding the effect of vitamin K3 on hepatoma cell growth is presented. In brief, exploration of cell growth activity has been identified with the action of p34(cdc2) kinase and its associated protein tyrosine phosphatase. After exploring a series of substituted derivatives of vitamin K and vitamin K3 oxide, we suggest a mechanism involving alkylation at the active-site cysteine for the inhibition of the protein tyrosine phosphatase which controls the activity of the p34(cdc2) kinase.",

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AU - Kerns, Jeffrey

AU - Naganathan, Sriram

AU - Dowd, Paul

AU - Finn, Frances M.

AU - Carr, Brian

PY - 1995

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AB - A new hypothesis regarding the effect of vitamin K3 on hepatoma cell growth is presented. In brief, exploration of cell growth activity has been identified with the action of p34(cdc2) kinase and its associated protein tyrosine phosphatase. After exploring a series of substituted derivatives of vitamin K and vitamin K3 oxide, we suggest a mechanism involving alkylation at the active-site cysteine for the inhibition of the protein tyrosine phosphatase which controls the activity of the p34(cdc2) kinase.

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Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep3B and HepG2 cells

Abstract

ASJC Scopus subject areas

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