Therapy of encephalopathy with status epilepticus during sleep (ESES/CSWS syndrome): An update

Pierangelo Veggiotti, Maria Carmela Pera, Federica Teutonico, Daniela Brazzo, Umberto Balottin, Carlo Alberto Tassinari

Research output: Contribution to journalArticlepeer-review


Electrical status epilepticus in sleep (ESES)/continuous spikes andwaves during slow sleep (CSWS) is an age-related, self-limiting disorder characterised by epilepsy with different seizure types, global or selective neuropsychological regression, motor impairment, and a typical EEG pattern of continuous epileptiform activity for more than 85% of non-rapid eye movement (NREM) sleep. Although the first description of ESES/CSWS dates back to 1971, an agreement about the optimal treatment for this condition is still lacking. ESES/CSWS is rare (incidence is 0.2-0.5% of all childhood epilepsies) and no controlled clinical trials have been conducted to establish the efficacy of different antiepileptic drugs; only uncontrolled studies and case reports are reported in the literature. Treatment options for ESES/CSWS include some antiepileptic drugs (valproic acid, ethosuximide, levetiracetam, and benzodiazepines), steroids, immunoglobulins, the ketogenic diet, and surgery (multiple subpial transections). In this study, the comparative value of each of these treatments is reviewed and a personal therapeutic approach is proposed.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalEpileptic Disorders
Issue number1
Publication statusPublished - Mar 2012


  • AEDs
  • ESES
  • Steroids

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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