TY - JOUR
T1 - Therapy of chronic hepatitis C with leukocyte interferon-α
AU - Toccaceli, F.
AU - Russo, V.
AU - Rosati, S.
AU - Iacomi, F.
AU - Monini, A.
AU - Canneti, A.
AU - Passarelli, F.
AU - Laghi, V.
PY - 1996
Y1 - 1996
N2 - Objectives. To evaluate biochemical, virologic and histologic effects of leukocyte IFN-α in chronic hepatitis C. Cases. 61 patients with chronic hepatitis C treated with 3 or 6 MU of IFN-α thrice a week for 12 or 24 months. Results. A complete biochemical response was observed in 50% of the patients after 6 months of treatment and in 58% after 12 months. Sustained responses were found, 3 and 6 months after the end of therapy, in 71% and 53% respectively of complete responders. Patients with undetectable pretreatment serum HCV-RNA showed, after 6 and 12 months of therapy, a higher complete response rate (57% and 75%, respectively) than patients with a positive HCV-RNA test (42% and 50%). Among patients with a high (≥10) pretreatment Knodell histologic activity index, after 6 months of therapy non-responders were more frequent (60%) than among patients with low (
AB - Objectives. To evaluate biochemical, virologic and histologic effects of leukocyte IFN-α in chronic hepatitis C. Cases. 61 patients with chronic hepatitis C treated with 3 or 6 MU of IFN-α thrice a week for 12 or 24 months. Results. A complete biochemical response was observed in 50% of the patients after 6 months of treatment and in 58% after 12 months. Sustained responses were found, 3 and 6 months after the end of therapy, in 71% and 53% respectively of complete responders. Patients with undetectable pretreatment serum HCV-RNA showed, after 6 and 12 months of therapy, a higher complete response rate (57% and 75%, respectively) than patients with a positive HCV-RNA test (42% and 50%). Among patients with a high (≥10) pretreatment Knodell histologic activity index, after 6 months of therapy non-responders were more frequent (60%) than among patients with low (
KW - chronic hepatitis
KW - HCV
KW - leukocyte interferon
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M3 - Article
AN - SCOPUS:0029931286
SN - 1127-6126
VL - 11
SP - 33
EP - 39
JO - Mediterranean Journal of Infectious and Parasitic Diseases
JF - Mediterranean Journal of Infectious and Parasitic Diseases
IS - 1
ER -