TY - JOUR
T1 - The Yin and Yang of CD4 + regulatory T cells in autoimmunity and cancer
AU - Galgani, M.
AU - Di Giacomo, A.
AU - Matarese, G.
AU - La Cava, A.
PY - 2009
Y1 - 2009
N2 - The immune system balances effector responses with tolerance, to protect the host from pathogens while minimizing local damage to tissue. An altered control of immune homeostasis can lead to loss of tolerance to self antigens in autoimmunity, or promote unwanted tolerance to tumor growth. This review focuses on the dual activity of CD4 + regulatory T cells (Tregs) in autoimmunity and cancer. Tregs play a key role in the mechanisms of immune tolerance and actively suppress pro-inflammatory responses, thus providing a beneficial action in autoimmunity and detrimental effects in cancer.
AB - The immune system balances effector responses with tolerance, to protect the host from pathogens while minimizing local damage to tissue. An altered control of immune homeostasis can lead to loss of tolerance to self antigens in autoimmunity, or promote unwanted tolerance to tumor growth. This review focuses on the dual activity of CD4 + regulatory T cells (Tregs) in autoimmunity and cancer. Tregs play a key role in the mechanisms of immune tolerance and actively suppress pro-inflammatory responses, thus providing a beneficial action in autoimmunity and detrimental effects in cancer.
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U2 - 10.2174/092986709789878201
DO - 10.2174/092986709789878201
M3 - Article
C2 - 19903146
AN - SCOPUS:72449153982
SN - 0929-8673
VL - 16
SP - 4626
EP - 4631
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 35
ER -