Abstract
To assess the frequency of cryptic subtelomeric rearrangements in children and adolescents with autism spectrum disorders, blood samples were studied using a complete set of subtelomeric FISH probes in 72 children with autism spectrum disorders. All children had normal high resolution karyotype, DNA fra-X analysis, brain MRI, metabolic work-up, and physical/neirological examination. Subtelomeric analysis did not detect abnormalities in any of the subjects, suggesting the uselessness of such investigations in individuals with primary autism spectrum disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 8-12 |
| Number of pages | 5 |
| Journal | American Journal of Medical Genetics, Part C: Seminars in Medical Genetics |
| Volume | 142 C |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 15 2006 |
Keywords
- Autism
- Autism spectrum disorders
- Pervasive developmental disorders
- Subtelomeric regions, subtelomeric FISH analysis
- Telomere
ASJC Scopus subject areas
- Genetics(clinical)
- Neuroscience(all)
- Neuropsychology and Physiological Psychology