The Vitamin D Role in Preventing Primary Headache in Adult and Pediatric Population

Giovanni Battista Dell'Isola, Eleonora Tulli, Rossella Sica, Valerio Vinti, Elisabetta Mencaroni, Giuseppe Di Cara, Pasquale Striano, Alberto Verrotti

Research output: Contribution to journalReview articlepeer-review


Headache is among the main neurological disorders with a great impact on both adults and children. The diagnosis of primary headache and proper management is often delayed with a great impact on work productivity and overall quality of life. Chronic headache often requires prophylactic therapy to reduce the frequency and severity of the attacks and the use of abortive medications. Besides the use of several classes of drugs, another treatment modality is the use of Nutraceuticals. Some studies have suggested a possible role of vitamin D in headache prophylaxis. Indeed, vitamin D is involved in several pathways of brain development, neuroprotection and neurotransmission. Moreover, there is data suggesting a close relationship between primary headache and vitamin D deficiency, both in children and in adults. To date, a few studies have evaluated the effect of vitamin D on headaches. The aim of this review is to summarize the data collected on headache prophylaxis with vitamin D comparing the effects of vitamin D in pediatric and adult populations.

Original languageEnglish
JournalJournal of Clinical Medicine
Issue number24
Publication statusPublished - Dec 20 2021


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