L'IMPIEGO IN TERAPIA DERMATOLOGICA DEGLI ESTRATTI DI AVOGADO E DI SOJA

The soap fraction of the vegetable oils of avocado and soya (1/3 avocado oil soap fraction with 2/3 soya oil soap fraction) was tested in scleroderma and in sclerodermiform conditions secondary to other skin diseases. The drug is already in use in France under the commercial name of Piascledine and is particularly rich in stigmaterol (vegetable sterol with precalciferolic activity) and although its action mechanism has not yet been definitively clarified, it would appear to affect the mobilization and utilization of calcium in the tissues. 28 patients were treated with a daily dose of 6 capsules for periods varying from a few months to over a year. Results were fairly satisfactory to the extent that repair time of sclerodermiform dermohypodermitic ulcerations was reduced. Subjectively, the patients noted a reduction of pain and less difficulty in performing movements. The drug was well tolerated; only 5 patients noticed slight signs of gastric intolerance (nausea, anorexia, vomiting) and 1 patient presented pruriginous symptomatology which regressed when the dose was reduced. It is concluded that although the drug does not resolve the etiological problem, it can be usefully employed alone or in association with other treatment, in the therapy of scleroderma and of secondary sclerodermiform states.