The unstable plaque

G. F. Gensini, B. Dilaghi

Research output: Contribution to journalArticlepeer-review


Acute thrombosis, which frequently complicates the evolution of atherosclerosis, leads to cardiovascular, cerebrovascular and peripheral events. Thrombosis occurs over plaques because of a disruption or tear in the cap of a lipid-rich plaque that leads to exposure of blood to highly thrombogenic plaque components because of denudation and erosion of the endothelial surface. Therefore, the crucial question is why atherosclerosis suddenly becomes complicated by life-threatening thrombosis. Plaque stabilization could be a crucial therapeutic intervention to combat the harmful consequences of coronary atherosclerosis through agents that can favourably impact on plaque pathobiology.

Original languageEnglish
JournalEuropean Heart Journal, Supplement
Issue numberB
Publication statusPublished - Mar 1 2002


  • Atherosclerosis
  • Passivation
  • Plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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