The unstable plaque

G. F. Gensini; B. Dilaghi

doi:10.1016/S1520-765X(02)90012-X

The unstable plaque

G. F. Gensini, B. Dilaghi

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Acute thrombosis, which frequently complicates the evolution of atherosclerosis, leads to cardiovascular, cerebrovascular and peripheral events. Thrombosis occurs over plaques because of a disruption or tear in the cap of a lipid-rich plaque that leads to exposure of blood to highly thrombogenic plaque components because of denudation and erosion of the endothelial surface. Therefore, the crucial question is why atherosclerosis suddenly becomes complicated by life-threatening thrombosis. Plaque stabilization could be a crucial therapeutic intervention to combat the harmful consequences of coronary atherosclerosis through agents that can favourably impact on plaque pathobiology.

Original language	English
Journal	European Heart Journal, Supplement
Volume	4
Issue number	B
DOIs	https://doi.org/10.1016/S1520-765X(02)90012-X
Publication status	Published - Mar 1 2002

Keywords

Atherosclerosis
Passivation
Plaque

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/S1520-765X(02)90012-X

Cite this

@article{c295a7fa322d494da70015b67f2cfc05,

title = "The unstable plaque",

abstract = "Acute thrombosis, which frequently complicates the evolution of atherosclerosis, leads to cardiovascular, cerebrovascular and peripheral events. Thrombosis occurs over plaques because of a disruption or tear in the cap of a lipid-rich plaque that leads to exposure of blood to highly thrombogenic plaque components because of denudation and erosion of the endothelial surface. Therefore, the crucial question is why atherosclerosis suddenly becomes complicated by life-threatening thrombosis. Plaque stabilization could be a crucial therapeutic intervention to combat the harmful consequences of coronary atherosclerosis through agents that can favourably impact on plaque pathobiology.",

keywords = "Atherosclerosis, Passivation, Plaque",

author = "Gensini, {G. F.} and B. Dilaghi",

year = "2002",

month = mar,

day = "1",

doi = "10.1016/S1520-765X(02)90012-X",

language = "English",

volume = "4",

journal = "European Heart Journal, Supplement",

issn = "1520-765X",

publisher = "Oxford University Press",

number = "B",

}

TY - JOUR

T1 - The unstable plaque

AU - Gensini, G. F.

AU - Dilaghi, B.

PY - 2002/3/1

Y1 - 2002/3/1

N2 - Acute thrombosis, which frequently complicates the evolution of atherosclerosis, leads to cardiovascular, cerebrovascular and peripheral events. Thrombosis occurs over plaques because of a disruption or tear in the cap of a lipid-rich plaque that leads to exposure of blood to highly thrombogenic plaque components because of denudation and erosion of the endothelial surface. Therefore, the crucial question is why atherosclerosis suddenly becomes complicated by life-threatening thrombosis. Plaque stabilization could be a crucial therapeutic intervention to combat the harmful consequences of coronary atherosclerosis through agents that can favourably impact on plaque pathobiology.

AB - Acute thrombosis, which frequently complicates the evolution of atherosclerosis, leads to cardiovascular, cerebrovascular and peripheral events. Thrombosis occurs over plaques because of a disruption or tear in the cap of a lipid-rich plaque that leads to exposure of blood to highly thrombogenic plaque components because of denudation and erosion of the endothelial surface. Therefore, the crucial question is why atherosclerosis suddenly becomes complicated by life-threatening thrombosis. Plaque stabilization could be a crucial therapeutic intervention to combat the harmful consequences of coronary atherosclerosis through agents that can favourably impact on plaque pathobiology.

KW - Atherosclerosis

KW - Passivation

KW - Plaque

UR - http://www.scopus.com/inward/record.url?scp=0141918656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141918656&partnerID=8YFLogxK

U2 - 10.1016/S1520-765X(02)90012-X

DO - 10.1016/S1520-765X(02)90012-X

M3 - Article

AN - SCOPUS:0141918656

SN - 1520-765X

VL - 4

JO - European Heart Journal, Supplement

JF - European Heart Journal, Supplement

IS - B

ER -

The unstable plaque

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this