TY - JOUR
T1 - The two-faced role of cad genes in the virulence of pathogenic Escherichia coli
AU - Prosseda, Gianni
AU - Carmela Latella, Maria
AU - Barbagallo, Marialuisa
AU - Nicoletti, Mauro
AU - Al Kassas, Rasha
AU - Casalino, Mariassunta
AU - Colonna, Bianca
PY - 2007/7
Y1 - 2007/7
N2 - In enterobacteria, acid stress induces expression of the cad system which is involved in maintaining intracellular pH at levels compatible with cell survival. Despite its crucial role, the cad operon is silenced in Shigella and in other pathogenic Escherichia coli. In the present review, we will address the question of why and how the cad locus has been sacrificed for the sake of optimal expression of virulence traits.
AB - In enterobacteria, acid stress induces expression of the cad system which is involved in maintaining intracellular pH at levels compatible with cell survival. Despite its crucial role, the cad operon is silenced in Shigella and in other pathogenic Escherichia coli. In the present review, we will address the question of why and how the cad locus has been sacrificed for the sake of optimal expression of virulence traits.
KW - Cad operon
KW - CadC regulator
KW - Genome evolution
KW - Pathoadaptive mutation
KW - Pathogenic Escherichia coli
UR - http://www.scopus.com/inward/record.url?scp=34547542124&partnerID=8YFLogxK
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U2 - 10.1016/j.resmic.2007.05.001
DO - 10.1016/j.resmic.2007.05.001
M3 - Article
C2 - 17656072
AN - SCOPUS:34547542124
SN - 0923-2508
VL - 158
SP - 487
EP - 493
JO - Research in Microbiology
JF - Research in Microbiology
IS - 6
ER -