The tetraspan MS4A family in homeostasis, immunity, and disease

Irene Mattiola; Alberto Mantovani; Massimo Locati

doi:10.1016/j.it.2021.07.002

The tetraspan MS4A family in homeostasis, immunity, and disease

Irene Mattiola, Alberto Mantovani, Massimo Locati

Istituto Clinico Humanitas

Research output: Contribution to journal › Review article › peer-review

Abstract

The membrane-spanning 4A (MS4A) family includes 18 members with a tetraspan structure in humans. They are differentially and selectively expressed in immunocompetent cells, such as B cells (CD20/MS4A1) and macrophages (MS4A4A), and associate with, and modulate the signaling activity of, different classes of immunoreceptor, including pattern recognition receptors (PRRs) and Ig receptors. Evidence from preclinical models and genetic evidence from humans suggest that members of the MS4A family have key roles in different pathological settings, including cancer, infectious diseases, and neurodegeneration. Therefore, MS4A family members might serve as candidate biomarkers and therapeutic targets for various conditions.

Original language	English
Pages (from-to)	764-781
Number of pages	18
Journal	Trends Immunol.
Volume	42
Issue number	9
DOIs	https://doi.org/10.1016/j.it.2021.07.002
Publication status	Published - Sept 2021

Keywords

Antigens, CD20
B-Lymphocytes
Disease
Homeostasis
Humans
Immunity
Macrophages
Membrane Proteins
Tetraspanins/physiology

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10.1016/j.it.2021.07.002

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title = "The tetraspan MS4A family in homeostasis, immunity, and disease",

abstract = "The membrane-spanning 4A (MS4A) family includes 18 members with a tetraspan structure in humans. They are differentially and selectively expressed in immunocompetent cells, such as B cells (CD20/MS4A1) and macrophages (MS4A4A), and associate with, and modulate the signaling activity of, different classes of immunoreceptor, including pattern recognition receptors (PRRs) and Ig receptors. Evidence from preclinical models and genetic evidence from humans suggest that members of the MS4A family have key roles in different pathological settings, including cancer, infectious diseases, and neurodegeneration. Therefore, MS4A family members might serve as candidate biomarkers and therapeutic targets for various conditions.",

keywords = "Antigens, CD20, B-Lymphocytes, Disease, Homeostasis, Humans, Immunity, Macrophages, Membrane Proteins, Tetraspanins/physiology",

author = "Irene Mattiola and Alberto Mantovani and Massimo Locati",

year = "2021",

month = sep,

doi = "10.1016/j.it.2021.07.002",

language = "English",

volume = "42",

pages = "764--781",

journal = "Trends Immunol.",

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TY - JOUR

T1 - The tetraspan MS4A family in homeostasis, immunity, and disease

AU - Mattiola, Irene

AU - Mantovani, Alberto

AU - Locati, Massimo

PY - 2021/9

Y1 - 2021/9

N2 - The membrane-spanning 4A (MS4A) family includes 18 members with a tetraspan structure in humans. They are differentially and selectively expressed in immunocompetent cells, such as B cells (CD20/MS4A1) and macrophages (MS4A4A), and associate with, and modulate the signaling activity of, different classes of immunoreceptor, including pattern recognition receptors (PRRs) and Ig receptors. Evidence from preclinical models and genetic evidence from humans suggest that members of the MS4A family have key roles in different pathological settings, including cancer, infectious diseases, and neurodegeneration. Therefore, MS4A family members might serve as candidate biomarkers and therapeutic targets for various conditions.

AB - The membrane-spanning 4A (MS4A) family includes 18 members with a tetraspan structure in humans. They are differentially and selectively expressed in immunocompetent cells, such as B cells (CD20/MS4A1) and macrophages (MS4A4A), and associate with, and modulate the signaling activity of, different classes of immunoreceptor, including pattern recognition receptors (PRRs) and Ig receptors. Evidence from preclinical models and genetic evidence from humans suggest that members of the MS4A family have key roles in different pathological settings, including cancer, infectious diseases, and neurodegeneration. Therefore, MS4A family members might serve as candidate biomarkers and therapeutic targets for various conditions.

KW - Antigens, CD20

KW - B-Lymphocytes

KW - Disease

KW - Homeostasis

KW - Humans

KW - Immunity

KW - Macrophages

KW - Membrane Proteins

KW - Tetraspanins/physiology

U2 - 10.1016/j.it.2021.07.002

DO - 10.1016/j.it.2021.07.002

M3 - Review article

C2 - 34384709

SN - 1471-4906

VL - 42

SP - 764

EP - 781

JO - Trends Immunol.

JF - Trends Immunol.

IS - 9

ER -

The tetraspan MS4A family in homeostasis, immunity, and disease

Abstract

Keywords

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