The Skin Neurotrophic Network in Health and Disease

R. G. Borroni; F. Truzzi; C. Pincelli

doi:10.1016/S0001-7310(09)73381-2

The Skin Neurotrophic Network in Health and Disease

R. G. Borroni, F. Truzzi, C. Pincelli

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Neurotrophins (NTs) belong to a family of structurally and functionally related proteins that, depending on the tissue context and the receptors involved, promote neuronal cell survival and differentiation or cell death. NTs also exert important functions in other organs besides the nervous system, including the skin. The presence in the skin of diverse cell types which are able to secrete and/or to respond to stimulation by NTs creates a unique network of molecular signaling in the cutaneous microenvironment. This review summarizes currently available data on the expression and function of NTs and their receptors in several cell types in the skin (namely, keratinocytes, melanocytes and fibroblasts). The role of the skin NT network in the development and maintenance of some relevant skin diseases is presented and the potential implications for therapeutic intervention are discussed.

Original language	English
Pages (from-to)	70-74
Number of pages	5
Journal	Actas Dermo-Sifiliograficas
Volume	100
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/S0001-7310(09)73381-2
Publication status	Published - Dec 2009

Keywords

melanoma
neurotrophins
p75NTR
psoriasis
skin
Trk

ASJC Scopus subject areas

Dermatology
Histology
Pathology and Forensic Medicine

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10.1016/S0001-7310(09)73381-2

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AU - Borroni, R. G.

AU - Truzzi, F.

AU - Pincelli, C.

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KW - psoriasis

KW - skin

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The Skin Neurotrophic Network in Health and Disease

Abstract

Keywords

ASJC Scopus subject areas

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