The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes

Antonio Ceriello; Valeria De Nigris; Gemma Pujadas; Lucia La Sala; Anna Rita Bonfigli; Roberto Testa; Annachiara Uccellatore; Stefano Genovese

doi:10.1016/j.diabres.2016.01.019

The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes

Antonio Ceriello, Valeria De Nigris, Gemma Pujadas, Lucia La Sala, Anna Rita Bonfigli, Roberto Testa, Annachiara Uccellatore, Stefano Genovese

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Background: To test the effect of normoglycemia and glucagon-like peptide-1 (GLP-1), alone or in combination, on the possible normalization of endothelial function in type 1 diabetes. Methods: Fifteen people with type 1 diabetes participated in three experiments: reaching and maintaining normoglycemia for 4 h; reaching and maintaining hyperglycemia plus GLP-1 infusion for 4 h; and reaching and maintaining normoglycemia for 4 h with simultaneous infusion of GLP-1. Results: Both normoglycemia and GLP-1 infusion restored endothelial function and decreased and plasma 8-iso prostaglandin F2α levels. However, only the combination of normoglycemia and GLP-1 was able to normalize endothelial function. Conclusions: This study confirms that long-lasting hyperglycemia in type 1 diabetes induces a permanent alteration which contributes to maintaining endothelial dysfunction even when glycemia is normalized, and that in the presence of normoglycemia, GLP-1 can contribute to normalizing endothelial function.

Original language	English
Pages (from-to)	64-68
Number of pages	5
Journal	Diabetes Research and Clinical Practice
Volume	114
DOIs	https://doi.org/10.1016/j.diabres.2016.01.019
Publication status	Published - Apr 1 2016

Keywords

Endothelial function
GLP-1
Metabolic memory
Oxidative stress
Type 1 diabetes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Internal Medicine
Endocrinology

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10.1016/j.diabres.2016.01.019

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title = "The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes",

abstract = "Background: To test the effect of normoglycemia and glucagon-like peptide-1 (GLP-1), alone or in combination, on the possible normalization of endothelial function in type 1 diabetes. Methods: Fifteen people with type 1 diabetes participated in three experiments: reaching and maintaining normoglycemia for 4 h; reaching and maintaining hyperglycemia plus GLP-1 infusion for 4 h; and reaching and maintaining normoglycemia for 4 h with simultaneous infusion of GLP-1. Results: Both normoglycemia and GLP-1 infusion restored endothelial function and decreased and plasma 8-iso prostaglandin F2α levels. However, only the combination of normoglycemia and GLP-1 was able to normalize endothelial function. Conclusions: This study confirms that long-lasting hyperglycemia in type 1 diabetes induces a permanent alteration which contributes to maintaining endothelial dysfunction even when glycemia is normalized, and that in the presence of normoglycemia, GLP-1 can contribute to normalizing endothelial function.",

keywords = "Endothelial function, GLP-1, Metabolic memory, Oxidative stress, Type 1 diabetes",

author = "Antonio Ceriello and {De Nigris}, Valeria and Gemma Pujadas and {La Sala}, Lucia and Bonfigli, {Anna Rita} and Roberto Testa and Annachiara Uccellatore and Stefano Genovese",

year = "2016",

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day = "1",

doi = "10.1016/j.diabres.2016.01.019",

language = "English",

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journal = "Diabetes Research and Clinical Practice",

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T1 - The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes

AU - Ceriello, Antonio

AU - De Nigris, Valeria

AU - Pujadas, Gemma

AU - La Sala, Lucia

AU - Bonfigli, Anna Rita

AU - Testa, Roberto

AU - Uccellatore, Annachiara

AU - Genovese, Stefano

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background: To test the effect of normoglycemia and glucagon-like peptide-1 (GLP-1), alone or in combination, on the possible normalization of endothelial function in type 1 diabetes. Methods: Fifteen people with type 1 diabetes participated in three experiments: reaching and maintaining normoglycemia for 4 h; reaching and maintaining hyperglycemia plus GLP-1 infusion for 4 h; and reaching and maintaining normoglycemia for 4 h with simultaneous infusion of GLP-1. Results: Both normoglycemia and GLP-1 infusion restored endothelial function and decreased and plasma 8-iso prostaglandin F2α levels. However, only the combination of normoglycemia and GLP-1 was able to normalize endothelial function. Conclusions: This study confirms that long-lasting hyperglycemia in type 1 diabetes induces a permanent alteration which contributes to maintaining endothelial dysfunction even when glycemia is normalized, and that in the presence of normoglycemia, GLP-1 can contribute to normalizing endothelial function.

AB - Background: To test the effect of normoglycemia and glucagon-like peptide-1 (GLP-1), alone or in combination, on the possible normalization of endothelial function in type 1 diabetes. Methods: Fifteen people with type 1 diabetes participated in three experiments: reaching and maintaining normoglycemia for 4 h; reaching and maintaining hyperglycemia plus GLP-1 infusion for 4 h; and reaching and maintaining normoglycemia for 4 h with simultaneous infusion of GLP-1. Results: Both normoglycemia and GLP-1 infusion restored endothelial function and decreased and plasma 8-iso prostaglandin F2α levels. However, only the combination of normoglycemia and GLP-1 was able to normalize endothelial function. Conclusions: This study confirms that long-lasting hyperglycemia in type 1 diabetes induces a permanent alteration which contributes to maintaining endothelial dysfunction even when glycemia is normalized, and that in the presence of normoglycemia, GLP-1 can contribute to normalizing endothelial function.

KW - Endothelial function

KW - GLP-1

KW - Metabolic memory

KW - Oxidative stress

KW - Type 1 diabetes

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JO - Diabetes Research and Clinical Practice

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The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes

Abstract

Keywords

ASJC Scopus subject areas

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