The role of the cell-cell interactions in cancer progression

Katarzyna Kamińska, Cezary Szczylik, Zofia F. Bielecka, Ewa Bartnik, Camillo Porta, Fei Lian, Anna M. Czarnecka

Research output: Contribution to journalArticlepeer-review


In the field of cancer research, scientific investigations are based on analysing differences in the secretome, the proteome, the transcriptome, the expression of cell surface molecules, and the deregulation of signal transduction pathways between neoplastic and normal cells. Accumulating evidence indicates a crucial role in carcinogenesis concerning not only stromal cells but also normal cells from target organs and tissue where tumours emerge. The tumour microenvironment (TME) definitively plays an important role in regulating neighbouring cell behaviour. To date, limited attention has been focused upon interactions between cancer cells and normal cells. This review concentrates on the interactions between stromal and healthy cells from the TME in cancer development. In the article, the authors also describe mutations, genes and proteins expression pattern that are involved in tumour development in target organ.

Original languageEnglish
Pages (from-to)283-296
Number of pages14
JournalJournal of Cellular and Molecular Medicine
Issue number2
Publication statusPublished - Feb 1 2015


  • Cancer
  • Cell-cell interactions
  • Stromal cells
  • Tumour microenvironment

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine


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