The role of neutropenia on outcomes of cancer patients with community-acquired pneumonia

S. Aliberti, J. A. Myers, P. Peyrani, F. Blasi, R. Menendez, P. Rossi, R. Cosentini, G. Lopardo, L. De Vedia, J. A. Ramirez

Research output: Contribution to journalArticlepeer-review


Although the presence of neutropenia may predispose cancer patients to develop community-acquired pneumonia, the role of neutropenia on their outcomes has not been investigated. The purpose of the present study was to compare clinical outcomes of cancer community-acquired pneumonia patients with and without neutropenia. Patients with cancer, identified in the Community-Acquired Pneumonia Organization database, were divided into two groups according to the type of cancer and the presence of neutropenia: patients with solid cancer without neutropenia versus those with functional or absolute neutropenia. Among the 3,106 community-acquired pneumonia patients enrolled, 135 had cancer without neutropenia and 75 had cancer with neutropenia. No significant difference was found between patients with and without neutropenia regarding mean time to clinical stability (5.4±2.7 versus 4.9±2.7 days, respectively), mean length of hospital stay (9.2±7.7 versus 9.9±9.6 days) and in-hospital mortality (18 versus 15%, respectively). Using a multiple logistic regression model, neutropenia was not associated with mortality in cancer patients when adjusting for significant covariates (odds ratio 1.30). Lack of neutropenia, during the initial evaluation of a cancer community-acquired pneumonia patient, should not be considered an indicator of better clinical outcome. Copyright

Original languageEnglish
Pages (from-to)142-147
Number of pages6
JournalEuropean Respiratory Journal
Issue number1
Publication statusPublished - Jan 2009


  • Cancer
  • Community-acquired pneumonia
  • Neutropenia
  • Outcomes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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