TY - JOUR
T1 - The role of mast cell in tissue morphogenesis. Thymus, duodenum, and mammary gland as examples
AU - Ribatti, Domenico
AU - Crivellato, Enrico
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Mast cells (MCs) are strategically located at host/environment interfaces like skin, airways, and gastro-intestinal and uro-genital tracts. MCs also populate connective tissues in association with blood and lymphatic vessels and nerves. MCs are absent in avascular tissues, such as mineralized bone, cartilage, and cornea. MCs have various functions and different functional subsets of MCs are encountered in different tissues. However, we do not' know exactly what is the physiological function of MC. Most of these functions are not essential for life, as various MC-deficient strains of mice and rats seems to have normal life spans. In this review article, we have reported and discussed the literature data concerning the role of MCs in tissue morphogenesis, and in particular their role in the development of thymus, duodenum, and mammary gland.
AB - Mast cells (MCs) are strategically located at host/environment interfaces like skin, airways, and gastro-intestinal and uro-genital tracts. MCs also populate connective tissues in association with blood and lymphatic vessels and nerves. MCs are absent in avascular tissues, such as mineralized bone, cartilage, and cornea. MCs have various functions and different functional subsets of MCs are encountered in different tissues. However, we do not' know exactly what is the physiological function of MC. Most of these functions are not essential for life, as various MC-deficient strains of mice and rats seems to have normal life spans. In this review article, we have reported and discussed the literature data concerning the role of MCs in tissue morphogenesis, and in particular their role in the development of thymus, duodenum, and mammary gland.
KW - Duodenum
KW - Mammary gland
KW - Mast cells
KW - Morphogenesis
KW - Thymus
UR - http://www.scopus.com/inward/record.url?scp=84958183709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958183709&partnerID=8YFLogxK
U2 - 10.1016/j.yexcr.2015.11.022
DO - 10.1016/j.yexcr.2015.11.022
M3 - Article
C2 - 26615957
AN - SCOPUS:84958183709
SN - 0014-4827
VL - 341
SP - 105
EP - 109
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 1
ER -