Abstract
Cerebral blood volume (CBV) was calculated in gerbils from specific-gravity (SG) changes between normal and saline-perfused brains. Furthermore, changes in CBV were investigated during ischemia using carbon-14-labeled dextran (MW 70,000) as an intravascular marker. Both data were used to evaluate the possible error due to a change in CBV on the measurement of ischemic brain edema by the SG method. The methodological error found was 0.0004 for a 100% CBV change. This error is insignificant, being less than the standard deviation in the SG measured for the gerbil cortex (SG 1.0494 ± 0.0006). Thus, CBV changes are not responsible for the SG variations observed during the first phase of ischemia. These variations are better explained as an increase of brain water content during ischemia.
| Original language | English |
|---|---|
| Pages (from-to) | 704-710 |
| Number of pages | 7 |
| Journal | Journal of Neurosurgery |
| Volume | 62 |
| Issue number | 5 |
| Publication status | Published - 1985 |
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)