TY - JOUR
T1 - The risk of extra-ovarian malignancies among women with endometriosis
T2 - A systematic literature review and meta-analysis
AU - Gandini, S.
AU - Lazzeroni, M.
AU - Peccatori, F. A.
AU - Bendinelli, B.
AU - Saieva, C.
AU - Palli, D.
AU - Masala, G.
AU - Caini, S.
PY - 2019/2
Y1 - 2019/2
N2 - We conducted a meta-analysis of studies reporting on the risk of extra-ovarian malignancies among women with endometriosis. Summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We explored causes of between-studies heterogeneity and assessed the presence of publication bias. We included 32 studies published between 1989 and 2018. We found an increased risk of endometrial (SRR 1.38, 95%CI 1.10–1.74) and thyroid cancer (SRR 1.38, 95%CI 1.17–1.63), and inverse association with cervical cancer (SRR 0.78, 95%CI 0.60–0.95). No association emerged for breast cancer (SRR 1.04, 95%CI 0.99–1.09) and melanoma (SRR 1.31, 95%CI 0.86–1.96). Between-study heterogeneity was large for breast and endometrial cancer and melanoma. Associations were generally stronger in case-control, cross-sectional, and cohort studies with internal control group, compared to cohort studies with external control group. No indication for publication bias was found. Our conclusions need to be confirmed in properly designed cohort studies with clinical confirmation of endometriosis.
AB - We conducted a meta-analysis of studies reporting on the risk of extra-ovarian malignancies among women with endometriosis. Summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We explored causes of between-studies heterogeneity and assessed the presence of publication bias. We included 32 studies published between 1989 and 2018. We found an increased risk of endometrial (SRR 1.38, 95%CI 1.10–1.74) and thyroid cancer (SRR 1.38, 95%CI 1.17–1.63), and inverse association with cervical cancer (SRR 0.78, 95%CI 0.60–0.95). No association emerged for breast cancer (SRR 1.04, 95%CI 0.99–1.09) and melanoma (SRR 1.31, 95%CI 0.86–1.96). Between-study heterogeneity was large for breast and endometrial cancer and melanoma. Associations were generally stronger in case-control, cross-sectional, and cohort studies with internal control group, compared to cohort studies with external control group. No indication for publication bias was found. Our conclusions need to be confirmed in properly designed cohort studies with clinical confirmation of endometriosis.
KW - Breast cancer
KW - Cervical cancer
KW - Endometrial cancer
KW - Endometriosis
KW - Melanoma
KW - Thyroid cancer
UR - http://www.scopus.com/inward/record.url?scp=85059781599&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059781599&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2018.12.009
DO - 10.1016/j.critrevonc.2018.12.009
M3 - Review article
C2 - 30771877
AN - SCOPUS:85059781599
SN - 1040-8428
VL - 134
SP - 72
EP - 81
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
ER -