The rational basis and the clinical value of selective cardiac sympathetic denervation in the prevention of malignant arrhythmias

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Abstract

We have shown that left-sided sympathetic cardiac nerves have a high arrhythmogenic potential and that their activation, particularly in ischaemic hearts, can rather easily trigger malignant ventricular arrhythmias. We have also shown that removal of these nerves has a potent antifibrillatory effect, with additional salutary actions on coronary flow. Clinically, selective sympathetic denervation defined as 'high thoracic left sympathectomy' is of definite value in the idiopathic long QT syndrome and, quite recently, has also seen found to be very effective in preventing sudden cardiac death in post-MI patients.

Original languageEnglish
Pages (from-to)107-118
Number of pages12
JournalEuropean Heart Journal
Volume7
Issue numberSUPPL. A
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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