The radioguided 111In-pentetreotide surgery in the management of ACTH-secreting bronchial carcinoid

V. Porziella, A. Cesario, Filippo Lococo, S. Cafarotti, S. Margaritora, G. D'Errico, R. Granone

Research output: Contribution to journalArticlepeer-review


Background and Objectives: A correct intra-operative detection of the tumour and, therefore, the complete surgical resection is critical to success in ACTH-secreting bronchial carcinoids. To date, all available preoperative and intra-operative procedures remain not entirely satisfactory. The use of intra-operative 111In-pentetreotide detection could offer a potentially reliable and rapid tool of real time assessment to achieve a radical resection. Materials and Methods: In two cases of ACTH-secreting bronchial carcinoids, after a preliminary 111In-pentetreotide scan, radio-guided surgery was performed using a hand-held gamma probe 24 h after i.v. administration of the tracer. Results: The 111In-pentetreotide radioguided surgery with hand-held gamma probe, if compared with pre-operative 111In-pentetreotide, significantly improved the intra-operative surgical management by detecting a millimetric nodule in one case; detecting mediastinal lymph node metastasis in both cases and ruling out any other disease localization. Discussion: Intra-operative 111In-pentetreotide detection appears to be safe and easy to perform. This technique allowed to achieve a complete resection of all the tumor locations, that would have been impossible to detect with conventional surgical approach. On the basis of these results we advocate for a wider investigation of the potentialities connected with the radioguided surgery coupled with pre-operative 111In- pentetreotide scan as a promising procedure in the management of ACTH-secreting bronchial carcinoids.

Original languageEnglish
Pages (from-to)587-591
Number of pages5
JournalEuropean Review for Medical and Pharmacological Sciences
Issue number6
Publication statusPublished - Jun 2011


  • In-pentetreotide
  • ACTH-secreting tumor
  • Bronchial carcinoid
  • Carcinoid tumors
  • Intraoperative detection bronchial tumor
  • Octreoscan

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)


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