The radial width of the temporal horn in mild cognitive impairment

Giovanni B. Frisoni, Roberta Rossi, Alberto Beltramello

Research output: Contribution to journalArticlepeer-review


Background and purpose. The diagnosis of preclinical Alzheimer's disease (AD) (or mild cognitive impairment [MCI]) is loaded with a high degree of uncertainty. The aim was to test the accuracy of a computed tomography-based (CT-based) marker of medial temporal lobe atrophy, the radial width of the temporal horn (rWTH), in MCI. Methods. Ten MCI and 42 AD patients and 29 nondemented controls underwent brain CT on the temporal lobe plane (slice thickness = 2 mm). The rWTH was taken on CT films with a precision caliper placed at the tip of the temporal horn radial to the curvature of the hippocampal head region. Results. When specificity was fixed at 95%, the sensitivity for the detection of AD was 39/42 (93%) and that for the detection of MCI was 8/10 (80%). Conclusion. The rWTH is a measure sensitive to the regional brain atrophy common in early AD.

Original languageEnglish
Pages (from-to)351-354
Number of pages4
JournalJournal of Neuroimaging
Issue number4
Publication statusPublished - Oct 2002


  • Computed tomography
  • Diagnosis
  • Medial temporal lobe
  • Mild cognitive impairment
  • Temporal horn

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology


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