The prevention and treatment of delirium in elderly patients following hip fracture surgery

Antonio Martocchia, Martina Curto, Fabrizia Comite, Sergio Scaccianoce, Paolo Girardi, Stefano Ferracuti, Ferdinando Nicoletti, Paolo Falaschi, Elisabetta De Marinis, Manuela Stefanelli, Lavinia Toussan, Antonio Devito, Stefania Giordano, Francesca Pastore, Ilaria Indiano, Stefano Eleuteri, Lisa Maccari, Giulia Maria Falaschi, Assunta De Luca, Matteo GallettaCarlo Turci, Paola Ladaga, Cristiana Luciani, Antonio Ientile, Stefania Vaglio, Maria Catanese, Maria Chiara Vulpiani, Laura Fiorani, Andrea Galassi, Letizia Simeoni, Enrico Ferri, Laura Tafaro, Massimiliano Rocchietti March, Rosalba Benvenuto, Carmelo D’Arrigo, Salvatore Di Somma, Massimo Volpe, Giovanni Pinto, Andrea Ferretti

Research output: Contribution to journalArticlepeer-review


Osteoporotic hip fracture needs a specific approach and treatment, since elderly patients are at high risk for adverse outcomes after surgery. In particular, delirium often occurs in the peri-operative period, and it is associated with death, hospital-acquired complications, persistent cognitive impairments, poor functional recovery after surgery and increased healthcare costs. The pre-operative assessment of the risk factors for delirium improves the preventive measures. The delirium diagnostic tools should be included in the standard of orthogeriatric cure for hip fracture. Given the increasing complexity of the clinical pictures, we present a review of the available treatment options for delirium in patients with hip fracture. The metabolic pre-operative disorders and the management of co-morbid diseases are specific targets of treatment in order to optimize the outcomes after surgery. In particular, elderly patients with Alzheimer’s disease are highly vulnerable to hip fracture and delirium, and they are severely frail with reduced physiologic reserves. An integrated approach combining environmental and pharmacological strategies is useful in the delirium treatment, with a close collaboration between the orthopedic and geriatric team.

Original languageEnglish
Pages (from-to)55-64
Number of pages10
JournalRecent Patents on CNS Drug Discovery
Issue number1
Publication statusPublished - Jul 1 2015


  • Alzheimer’s disease
  • BDNF
  • Cortisol
  • Hip fracture
  • Metabolism
  • Neurotransmission

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Drug Discovery


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