The ovariectomized ewe model in the evaluation of biomaterials for prosthetic devices in spinal fixation

Gianluca Giavaresi; M. Fini; P. Torricelli; L. Martini; R. Giardino

The ovariectomized ewe model in the evaluation of biomaterials for prosthetic devices in spinal fixation

Gianluca Giavaresi, M. Fini, P. Torricelli, L. Martini, R. Giardino

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of surgical ovariectomy on cancellous bone was investigated by comparing mechanical properties and microarchitectural characteristics of the lumbar vertebrae in ovariectomized and sham-operated ewes. Eighteen mongrel ewes, 4±1 years old, were randomly divided into three groups: 6 animals served as a control group (Baseline), 6 were bilaterally ovariectomized (OVX), and the others were used as a sham-operated group (SHAM). OVX and SHAM ewes were euthanized 24 months after surgery; the L5 vertebrae were processed for mechanical and histomorphometric analyses. Maximum load, maximum strength (p

Original language	English
Pages (from-to)	814-820
Number of pages	7
Journal	International Journal of Artificial Organs
Volume	24
Issue number	11
Publication status	Published - 2001

Keywords

Biomaterials
Osteopenia
Osteoporosis
Sheep
Spine

ASJC Scopus subject areas

Biophysics

Cite this

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AU - Martini, L.

AU - Giardino, R.

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KW - Osteopenia

KW - Osteoporosis

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KW - Spine

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The ovariectomized ewe model in the evaluation of biomaterials for prosthetic devices in spinal fixation

Abstract

Keywords

ASJC Scopus subject areas

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