The New World Health Organization Classification for Pancreatic Neuroendocrine Neoplasia

Frediano Inzani; Gianluigi Petrone; Guido Rindi

doi:10.1016/j.ecl.2018.04.008

The New World Health Organization Classification for Pancreatic Neuroendocrine Neoplasia

Frediano Inzani, Gianluigi Petrone, Guido Rindi

IRCCS Fondazione Policlinico Universitario A. Gemelli

Research output: Contribution to journal › Review article › peer-review

Abstract

Based on the 2010 version, the 2017 World Health Organization (WHO 2017) classification is for pancreatic neuroendocrine neoplasms (PanNEN). The WHO 2017 classification introduces the novel well-differentiated neuroendocrine tumor of high grade (NET G3). A sharp distinction between NET and poorly differentiated neuroendocrine carcinoma (NEC) is emphasized to highlight substantial biological differences. Further changes comprise the definition of mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN), to accommodate all grades of both neoplasm components, and the abolition of preneoplastic lesions given their rarity in the pancreas. The 2017 American Joint Cancer Committee classification (AJCC 2017) adopts such a classification for all digestive sites.

Original language	English
Pages (from-to)	463-470
Number of pages	8
Journal	Endocrinology and Metabolism Clinics of North America
Volume	47
Issue number	3
DOIs	https://doi.org/10.1016/j.ecl.2018.04.008
Publication status	Published - Sept 1 2018

Keywords

American Joint Cancer Committee
Ki67
Neuroendocrine carcinoma
Neuroendocrine neoplasm
Neuroendocrine tumor
World Health Organization

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.ecl.2018.04.008

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title = "The New World Health Organization Classification for Pancreatic Neuroendocrine Neoplasia",

abstract = "Based on the 2010 version, the 2017 World Health Organization (WHO 2017) classification is for pancreatic neuroendocrine neoplasms (PanNEN). The WHO 2017 classification introduces the novel well-differentiated neuroendocrine tumor of high grade (NET G3). A sharp distinction between NET and poorly differentiated neuroendocrine carcinoma (NEC) is emphasized to highlight substantial biological differences. Further changes comprise the definition of mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN), to accommodate all grades of both neoplasm components, and the abolition of preneoplastic lesions given their rarity in the pancreas. The 2017 American Joint Cancer Committee classification (AJCC 2017) adopts such a classification for all digestive sites.",

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author = "Frediano Inzani and Gianluigi Petrone and Guido Rindi",

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AU - Inzani, Frediano

AU - Petrone, Gianluigi

AU - Rindi, Guido

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N2 - Based on the 2010 version, the 2017 World Health Organization (WHO 2017) classification is for pancreatic neuroendocrine neoplasms (PanNEN). The WHO 2017 classification introduces the novel well-differentiated neuroendocrine tumor of high grade (NET G3). A sharp distinction between NET and poorly differentiated neuroendocrine carcinoma (NEC) is emphasized to highlight substantial biological differences. Further changes comprise the definition of mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN), to accommodate all grades of both neoplasm components, and the abolition of preneoplastic lesions given their rarity in the pancreas. The 2017 American Joint Cancer Committee classification (AJCC 2017) adopts such a classification for all digestive sites.

AB - Based on the 2010 version, the 2017 World Health Organization (WHO 2017) classification is for pancreatic neuroendocrine neoplasms (PanNEN). The WHO 2017 classification introduces the novel well-differentiated neuroendocrine tumor of high grade (NET G3). A sharp distinction between NET and poorly differentiated neuroendocrine carcinoma (NEC) is emphasized to highlight substantial biological differences. Further changes comprise the definition of mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN), to accommodate all grades of both neoplasm components, and the abolition of preneoplastic lesions given their rarity in the pancreas. The 2017 American Joint Cancer Committee classification (AJCC 2017) adopts such a classification for all digestive sites.

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KW - Neuroendocrine carcinoma

KW - Neuroendocrine neoplasm

KW - Neuroendocrine tumor

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The New World Health Organization Classification for Pancreatic Neuroendocrine Neoplasia

Abstract

Keywords

ASJC Scopus subject areas

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