The New World Health Organization Classification for Pancreatic Neuroendocrine Neoplasia

Frediano Inzani, Gianluigi Petrone, Guido Rindi

Research output: Contribution to journalReview articlepeer-review


Based on the 2010 version, the 2017 World Health Organization (WHO 2017) classification is for pancreatic neuroendocrine neoplasms (PanNEN). The WHO 2017 classification introduces the novel well-differentiated neuroendocrine tumor of high grade (NET G3). A sharp distinction between NET and poorly differentiated neuroendocrine carcinoma (NEC) is emphasized to highlight substantial biological differences. Further changes comprise the definition of mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN), to accommodate all grades of both neoplasm components, and the abolition of preneoplastic lesions given their rarity in the pancreas. The 2017 American Joint Cancer Committee classification (AJCC 2017) adopts such a classification for all digestive sites.

Original languageEnglish
Pages (from-to)463-470
Number of pages8
JournalEndocrinology and Metabolism Clinics of North America
Issue number3
Publication statusPublished - Sept 1 2018


  • American Joint Cancer Committee
  • Ki67
  • Neuroendocrine carcinoma
  • Neuroendocrine neoplasm
  • Neuroendocrine tumor
  • World Health Organization

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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