Valutazione morfologica dell'infiltrazione midollare nel neuroblastoma.

Translated title of the contribution: The morphological assessment of bone marrow infiltration in neuroblastoma

M. Brisigotti, D. Medicina, L. Bercich, M. F. Bonetti, G. Fabbretti, C. Gambini, M. S. Lo Piccolo, C. Milanaccio, C. Rosanda, A. Garaventa, B. De Bernardi, F. Callea

Research output: Contribution to journalArticlepeer-review


Bone marrow biopsy is very important in diagnosis and follow-up of children affected by neuroblastoma (NB). Between June 1995 and May 1997 we studied 55 patients with NB stage 4. Specimens were obtained at the diagnosis (in 8 patients) and after chemotherapy (in 55 patients) in order to evaluate the effects of treatment on bone marrow disease. 88% of 343 biopsies were representative versus 99% of 639 aspirates. Of 8 stage 4 patients evaluated at diagnosis, 15/16 biopsies versus 9/15 aspirates were positive. Following chemotherapy, out of 298 evaluable sites examined, 111 biopsies versus 30 aspirates (37 versus 10%) were positive. Of 111 positive biopsies 53 showed a focal pattern (35 differentiated, 18 undifferentiated), while 51 showed a diffuse pattern (18 differentiated, 40 undifferentiated). Our results confirm previous literature data indicating a better efficacy of histology versus morphology in detecting residual bone marrow disease (especially in case of focal differentiated pattern). The recent introduction of a specific monoclonal antibody, called anti-GD2, has improved our capacity to detect minimal residual disease in patients' bone marrow. The inclusion of anti-GD2 immunohistochemistry in our evaluation will possibly increase our overall sensitivity to detect minimal residual disease and may provide information capable to direct the physician's decision into a more rational patient's treatment.

Translated title of the contributionThe morphological assessment of bone marrow infiltration in neuroblastoma
Original languageItalian
Pages (from-to)169-174
Number of pages6
JournalPediatria Medica e Chirurgica
Issue number3
Publication statusPublished - May 1998

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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