The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin

Brian Ell; Qiong Qiu; Yong Wei; Laura Mercatali; Toni Ibrahim; Dino Amadori; Yibin Kang

doi:10.1074/jbc.M114.582866

The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin

Brian Ell, Qiong Qiu, Yong Wei, Laura Mercatali, Toni Ibrahim, Dino Amadori, Yibin Kang

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The role of microRNA (miRNA)-23b/27b/24 in metastasis is controversial. Results: Ectopic expression of the miRNA-23b/27b/24 cluster enhances metastasis in vivo by direct inhibition of prosaposin (PSAP). Conclusion: PSAP is a metastasis suppressor that is targeted by miRNA-23b/27b/24 in breast cancer. Significance: This finding represents a novel miRNA-target interaction for therapeutic intervention of breast cancer metastasis.

Original language	English
Pages (from-to)	21888-21895
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.582866
Publication status	Published - Aug 8 2014

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

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10.1074/jbc.M114.582866

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title = "The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin",

abstract = "Background: The role of microRNA (miRNA)-23b/27b/24 in metastasis is controversial. Results: Ectopic expression of the miRNA-23b/27b/24 cluster enhances metastasis in vivo by direct inhibition of prosaposin (PSAP). Conclusion: PSAP is a metastasis suppressor that is targeted by miRNA-23b/27b/24 in breast cancer. Significance: This finding represents a novel miRNA-target interaction for therapeutic intervention of breast cancer metastasis.",

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AU - Ell, Brian

AU - Qiu, Qiong

AU - Wei, Yong

AU - Mercatali, Laura

AU - Ibrahim, Toni

AU - Amadori, Dino

AU - Kang, Yibin

PY - 2014/8/8

Y1 - 2014/8/8

N2 - Background: The role of microRNA (miRNA)-23b/27b/24 in metastasis is controversial. Results: Ectopic expression of the miRNA-23b/27b/24 cluster enhances metastasis in vivo by direct inhibition of prosaposin (PSAP). Conclusion: PSAP is a metastasis suppressor that is targeted by miRNA-23b/27b/24 in breast cancer. Significance: This finding represents a novel miRNA-target interaction for therapeutic intervention of breast cancer metastasis.

AB - Background: The role of microRNA (miRNA)-23b/27b/24 in metastasis is controversial. Results: Ectopic expression of the miRNA-23b/27b/24 cluster enhances metastasis in vivo by direct inhibition of prosaposin (PSAP). Conclusion: PSAP is a metastasis suppressor that is targeted by miRNA-23b/27b/24 in breast cancer. Significance: This finding represents a novel miRNA-target interaction for therapeutic intervention of breast cancer metastasis.

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The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin

Abstract

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