The interleukin 1-β exonic (+3953) polymorphism does not alter in vitro protein secretion

Roberto Dominici; Giulia Malferrari; Claudio Mariani; Luigi M E Grimaldi; Ida Biunno

doi:10.1006/exmp.2002.2435

The interleukin 1-β exonic (+3953) polymorphism does not alter in vitro protein secretion

Roberto Dominici, Giulia Malferrari, Claudio Mariani, Luigi M E Grimaldi, Ida Biunno

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Several studies have described polymorphisms in the genes encoding interleukin-1α (IL-1α) and IL-1β cytokines and their implication in the onset of Alzheimer disease or in linkage disequilibrium with an as yet to be identified second locus on chromosome 2. However, these results have been associated with the sporadic forms of Alzheimer disease. Here we present data on the effects of the interleukin 1-β exonic polymorphism (+3953) using a series of cohort healthy control samples and in vitro protein secretion assays.

Original language	English
Pages (from-to)	139-141
Number of pages	3
Journal	Experimental and Molecular Pathology
Volume	73
Issue number	2
DOIs	https://doi.org/10.1006/exmp.2002.2435
Publication status	Published - 2002

ASJC Scopus subject areas

Clinical Biochemistry
Molecular Biology
Pathology and Forensic Medicine

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abstract = "Several studies have described polymorphisms in the genes encoding interleukin-1α (IL-1α) and IL-1β cytokines and their implication in the onset of Alzheimer disease or in linkage disequilibrium with an as yet to be identified second locus on chromosome 2. However, these results have been associated with the sporadic forms of Alzheimer disease. Here we present data on the effects of the interleukin 1-β exonic polymorphism (+3953) using a series of cohort healthy control samples and in vitro protein secretion assays.",

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AU - Mariani, Claudio

AU - Grimaldi, Luigi M E

AU - Biunno, Ida

PY - 2002

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AB - Several studies have described polymorphisms in the genes encoding interleukin-1α (IL-1α) and IL-1β cytokines and their implication in the onset of Alzheimer disease or in linkage disequilibrium with an as yet to be identified second locus on chromosome 2. However, these results have been associated with the sporadic forms of Alzheimer disease. Here we present data on the effects of the interleukin 1-β exonic polymorphism (+3953) using a series of cohort healthy control samples and in vitro protein secretion assays.

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The interleukin 1-β exonic (+3953) polymorphism does not alter in vitro protein secretion

Abstract

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