The impact of histopathologic diagnosis on the proper management of testis neoplasms

Giovanni Ponti; Maurilio Ponzoni; Andrés J M Ferreri; Marco Foppoli; Luca Mazzucchelli; Emanuele Zucca

doi:10.1038/ncponc1218

The impact of histopathologic diagnosis on the proper management of testis neoplasms

Giovanni Ponti, Maurilio Ponzoni, Andrés J M Ferreri, Marco Foppoli, Luca Mazzucchelli, Emanuele Zucca

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background: A 45-year-old man underwent a right orchiectomy for a rapidly growing testicular mass. After histologic and imaging examinations the patient was diagnosed with stage I (T1N0M0) seminoma. Approximately 2 months after surgery the patient began to complain of abdominal pain and a CT scan revealed a bulky retroperitoneal mass. The patient did not receive the planned prophylactic radiotherapy and was treated with combined cisplatin, etoposide and bleomycin chemotherapy; after the completion of this treatment he achieved complete remission. Three years later, and while still undergoing follow-up, the patient developed multiple neurological motor deficits. Investigations: Brain MRI and CT-guided biopsy. Diagnosis: Diffuse large B-cell lymphoma of the testis, relapsing in the central nervous system. Management: High-dose methotrexate alone or in combination with high-dose cytarabine.

Original language	English
Pages (from-to)	619-622
Number of pages	4
Journal	Nature Clinical Practice Oncology
Volume	5
Issue number	10
DOIs	https://doi.org/10.1038/ncponc1218
Publication status	Published - 2008

ASJC Scopus subject areas

Oncology

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10.1038/ncponc1218

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title = "The impact of histopathologic diagnosis on the proper management of testis neoplasms",

abstract = "Background: A 45-year-old man underwent a right orchiectomy for a rapidly growing testicular mass. After histologic and imaging examinations the patient was diagnosed with stage I (T1N0M0) seminoma. Approximately 2 months after surgery the patient began to complain of abdominal pain and a CT scan revealed a bulky retroperitoneal mass. The patient did not receive the planned prophylactic radiotherapy and was treated with combined cisplatin, etoposide and bleomycin chemotherapy; after the completion of this treatment he achieved complete remission. Three years later, and while still undergoing follow-up, the patient developed multiple neurological motor deficits. Investigations: Brain MRI and CT-guided biopsy. Diagnosis: Diffuse large B-cell lymphoma of the testis, relapsing in the central nervous system. Management: High-dose methotrexate alone or in combination with high-dose cytarabine.",

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AU - Ponti, Giovanni

AU - Ponzoni, Maurilio

AU - Ferreri, Andrés J M

AU - Foppoli, Marco

AU - Mazzucchelli, Luca

AU - Zucca, Emanuele

PY - 2008

Y1 - 2008

N2 - Background: A 45-year-old man underwent a right orchiectomy for a rapidly growing testicular mass. After histologic and imaging examinations the patient was diagnosed with stage I (T1N0M0) seminoma. Approximately 2 months after surgery the patient began to complain of abdominal pain and a CT scan revealed a bulky retroperitoneal mass. The patient did not receive the planned prophylactic radiotherapy and was treated with combined cisplatin, etoposide and bleomycin chemotherapy; after the completion of this treatment he achieved complete remission. Three years later, and while still undergoing follow-up, the patient developed multiple neurological motor deficits. Investigations: Brain MRI and CT-guided biopsy. Diagnosis: Diffuse large B-cell lymphoma of the testis, relapsing in the central nervous system. Management: High-dose methotrexate alone or in combination with high-dose cytarabine.

AB - Background: A 45-year-old man underwent a right orchiectomy for a rapidly growing testicular mass. After histologic and imaging examinations the patient was diagnosed with stage I (T1N0M0) seminoma. Approximately 2 months after surgery the patient began to complain of abdominal pain and a CT scan revealed a bulky retroperitoneal mass. The patient did not receive the planned prophylactic radiotherapy and was treated with combined cisplatin, etoposide and bleomycin chemotherapy; after the completion of this treatment he achieved complete remission. Three years later, and while still undergoing follow-up, the patient developed multiple neurological motor deficits. Investigations: Brain MRI and CT-guided biopsy. Diagnosis: Diffuse large B-cell lymphoma of the testis, relapsing in the central nervous system. Management: High-dose methotrexate alone or in combination with high-dose cytarabine.

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The impact of histopathologic diagnosis on the proper management of testis neoplasms

Abstract

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