The immune network in thyroid cancer

Maria Rosaria Galdiero, Gilda Varricchi, Gianni Marone

Research output: Contribution to journalReview articlepeer-review


The immune system plays critical roles in tumor prevention, but also in its initiation and progression. Tumors are subjected to immunosurveillance, but cancer cells generate an immunosuppressive microenvironment that favors their escape from immune-mediated elimination. During chronic inflammation, immune cells can contribute to the formation and progression of tumors by producing mitogenic, prosurvival, proangiogenic and lymphangiogenic factors. Thyroid cancer is the most frequent type of endocrine neoplasia and is the most rapidly increasing cancer in the US. In this review, we discuss recent findings on how different immune cells and mediators can contribute to thyroid cancer development and progression.

Original languageEnglish
Article numbere1168556
Issue number6
Publication statusPublished - Jun 2 2016


  • Angiogenesis
  • chemokines
  • CXCL8/IL-8
  • dendritic cells
  • lymphangiogenesis
  • macrophages
  • mast cells
  • neutrophils
  • T reg cells
  • thyroid cancer

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology


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