the human α3b is a 'full-sized' laminin chain variant with a more widespread tissue expression than the truncated α3a

Roberto Doliana; Isabella Bellina; Francesco Bucciotti; Maurizio Mongiat; Roberto Perris; Alfonso Colombatti

doi:10.1016/S0014-5793(97)01251-9

the human α3b is a 'full-sized' laminin chain variant with a more widespread tissue expression than the truncated α3a

Roberto Doliana, Isabella Bellina, Francesco Bucciotti, Maurizio Mongiat, Roberto Perris, Alfonso Colombatti

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

We report the molecular cloning of the human laminin α3b chain variant and its mRNA expression pattern in adult human tissues when compared to the α3a variant. The mRNA encoding for the α3b variant is about 11 kb and the predicted translation product carries the complete set of domains typical for a 'full-sized' laminin α chain. Apart from the similar domain structure of α3b also the sequence of α3 resulted more closely related to the α5 than to the α4 chain. Quantitative analysis of the RNA expression in a broad panel of adult human tissues indicated that the α3b variant is more midely distributed than the α3a shorter variant.

Original language	English
Pages (from-to)	65-70
Number of pages	6
Journal	FEBS Letters
Volume	417
Issue number	1
DOIs	https://doi.org/10.1016/S0014-5793(97)01251-9
Publication status	Published - Nov 3 1997

Keywords

α Chain
Human laminin
Tissue expression

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1016/S0014-5793(97)01251-9

Cite this

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abstract = "We report the molecular cloning of the human laminin α3b chain variant and its mRNA expression pattern in adult human tissues when compared to the α3a variant. The mRNA encoding for the α3b variant is about 11 kb and the predicted translation product carries the complete set of domains typical for a 'full-sized' laminin α chain. Apart from the similar domain structure of α3b also the sequence of α3 resulted more closely related to the α5 than to the α4 chain. Quantitative analysis of the RNA expression in a broad panel of adult human tissues indicated that the α3b variant is more midely distributed than the α3a shorter variant.",

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AU - Doliana, Roberto

AU - Bellina, Isabella

AU - Bucciotti, Francesco

AU - Mongiat, Maurizio

AU - Perris, Roberto

AU - Colombatti, Alfonso

PY - 1997/11/3

Y1 - 1997/11/3

N2 - We report the molecular cloning of the human laminin α3b chain variant and its mRNA expression pattern in adult human tissues when compared to the α3a variant. The mRNA encoding for the α3b variant is about 11 kb and the predicted translation product carries the complete set of domains typical for a 'full-sized' laminin α chain. Apart from the similar domain structure of α3b also the sequence of α3 resulted more closely related to the α5 than to the α4 chain. Quantitative analysis of the RNA expression in a broad panel of adult human tissues indicated that the α3b variant is more midely distributed than the α3a shorter variant.

AB - We report the molecular cloning of the human laminin α3b chain variant and its mRNA expression pattern in adult human tissues when compared to the α3a variant. The mRNA encoding for the α3b variant is about 11 kb and the predicted translation product carries the complete set of domains typical for a 'full-sized' laminin α chain. Apart from the similar domain structure of α3b also the sequence of α3 resulted more closely related to the α5 than to the α4 chain. Quantitative analysis of the RNA expression in a broad panel of adult human tissues indicated that the α3b variant is more midely distributed than the α3a shorter variant.

KW - α Chain

KW - Human laminin

KW - Tissue expression

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the human α3b is a 'full-sized' laminin chain variant with a more widespread tissue expression than the truncated α3a

Abstract

Keywords

ASJC Scopus subject areas

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