TY - JOUR
T1 - The FTO gene is associated with a paradoxically favorable cardiometabolic risk profile in frail, obese older adults
AU - Armamento-Villareal, Reina
AU - Wingkun, Neil
AU - Aguirre, Lina E.
AU - Kulkarny, Vibhati
AU - Napoli, Nicola
AU - Colleluori, Georgia
AU - Qualls, Clifford
AU - Villareal, Dennis T.
PY - 2015/12/24
Y1 - 2015/12/24
N2 - OBJECTIVE: Fat mass and obesity-associated (FTO) gene polymorphisms have been reported to be associated with differences in BMI, obesity, and type 2 diabetes. However, previous studies have been predominantly conducted in younger individuals across a spectrum of body weights, whereas little information is available on the older population. We examined the association of FTO gene polymorphisms with cardiometabolic risks among adults who were both obese (BMI≥30 kg/m) and older (age≥65 years). METHODS: A total of 165 frail, obese older adults were genotyped for FTO (rs9939609 and rs8050136) single nucleotide polymorphisms and studied for associations with body weight and body composition, components and prevalence of the metabolic syndrome, insulin response to an oral glucose tolerance test, and levels of adipocytokines (e.g. leptin) and vitamin D. RESULTS: Carriers of the A allele (CA/AA) of the FTO single nucleotide polymorphism rs8050136 had lower body weight, BMI, body fat, and trunk fat than those without the A allele (CC genotype; all P’s
AB - OBJECTIVE: Fat mass and obesity-associated (FTO) gene polymorphisms have been reported to be associated with differences in BMI, obesity, and type 2 diabetes. However, previous studies have been predominantly conducted in younger individuals across a spectrum of body weights, whereas little information is available on the older population. We examined the association of FTO gene polymorphisms with cardiometabolic risks among adults who were both obese (BMI≥30 kg/m) and older (age≥65 years). METHODS: A total of 165 frail, obese older adults were genotyped for FTO (rs9939609 and rs8050136) single nucleotide polymorphisms and studied for associations with body weight and body composition, components and prevalence of the metabolic syndrome, insulin response to an oral glucose tolerance test, and levels of adipocytokines (e.g. leptin) and vitamin D. RESULTS: Carriers of the A allele (CA/AA) of the FTO single nucleotide polymorphism rs8050136 had lower body weight, BMI, body fat, and trunk fat than those without the A allele (CC genotype; all P’s
UR - http://www.scopus.com/inward/record.url?scp=84951968798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951968798&partnerID=8YFLogxK
U2 - 10.1097/FPC.0000000000000201
DO - 10.1097/FPC.0000000000000201
M3 - Article
AN - SCOPUS:84951968798
SN - 1744-6872
JO - Pharmacogenetics and Genomics
JF - Pharmacogenetics and Genomics
ER -