TY - JOUR
T1 - The effects of atorvastatin treatment on the mean platelet volume and red cell distribution width in patients with dyslipoproteinemia and comparison with plasma atherogenicity indicators-A pilot study
AU - Kucera, Marek
AU - Balaz, David
AU - Kruzliak, Peter
AU - Ciccocioppo, Rachele
AU - Oravec, Stanislav
AU - Rodrigo, Luis
AU - Zulli, Anthony
AU - Hirnerova, Eva
AU - Sabaka, Peter
AU - Komornikova, Andrea
AU - Sabo, Jan
AU - Slezak, Peter
AU - Gaspar, Ludovit
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Objectives: The mean platelet volume (MPV) and red cell distribution width (RDW) have recently arisen interest because of their association with an increased cardiovascular risk. The aim of our study was, therefore, to determine whether an association exists between MPV, RDW and lipoprotein sub-fractions, and to show the impact of statin therapy on these new possible biomarkers of atherosclerotic risk. Design and methods: A cohort of 40 patients with hypercholesterolaemia (29 females, mean age 62.9. ±. 9. years), without previous hypolipidaemic treatment were enrolled. The patients were treated with atorvastatin 40. mg/day for 12. weeks. Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density cholesterol (HDL-C), triglycerides (TG), LDL-C sub-fractions [large LDL-C 1-2 and small dense (sd)-LDL-C 3-7], apolipoproteins (apoA1, apoB), apoB/apoA1 ratio, atherogenic index of plasma (AIP), haematological parameters (including MPV, RDW) and safety parameters (renal, hepatic) were measured before and after 12. weeks of atorvastatin treatment. Results: At baseline, a strong correlation between HDL-C, TG, sd-LDL-C, apoB, apoB/apoA1, and AIP with MPV (. r=. -. 0.55, p
AB - Objectives: The mean platelet volume (MPV) and red cell distribution width (RDW) have recently arisen interest because of their association with an increased cardiovascular risk. The aim of our study was, therefore, to determine whether an association exists between MPV, RDW and lipoprotein sub-fractions, and to show the impact of statin therapy on these new possible biomarkers of atherosclerotic risk. Design and methods: A cohort of 40 patients with hypercholesterolaemia (29 females, mean age 62.9. ±. 9. years), without previous hypolipidaemic treatment were enrolled. The patients were treated with atorvastatin 40. mg/day for 12. weeks. Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density cholesterol (HDL-C), triglycerides (TG), LDL-C sub-fractions [large LDL-C 1-2 and small dense (sd)-LDL-C 3-7], apolipoproteins (apoA1, apoB), apoB/apoA1 ratio, atherogenic index of plasma (AIP), haematological parameters (including MPV, RDW) and safety parameters (renal, hepatic) were measured before and after 12. weeks of atorvastatin treatment. Results: At baseline, a strong correlation between HDL-C, TG, sd-LDL-C, apoB, apoB/apoA1, and AIP with MPV (. r=. -. 0.55, p
KW - Atherogenic dyslipidaemia
KW - Atorvastatin
KW - Dense LDL
KW - Mean platelet volume
KW - Red cell distribution width
KW - Small
UR - http://www.scopus.com/inward/record.url?scp=84929945116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929945116&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2015.02.010
DO - 10.1016/j.clinbiochem.2015.02.010
M3 - Article
C2 - 25727667
AN - SCOPUS:84929945116
SN - 0009-9120
VL - 48
SP - 557
EP - 561
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 9
ER -