TY - JOUR
T1 - The effects of a soy rich diet on serum lipids
T2 - The Menfis randomized trial
AU - Chiechi, L. M.
AU - Secreto, G.
AU - Vimercati, A.
AU - Greco, P.
AU - Venturelli, E.
AU - Pansini, F.
AU - Fanelli, M.
AU - Loizzi, P.
AU - Selvaggi, L.
PY - 2002/2/26
Y1 - 2002/2/26
N2 - Objective: To assess beneficial effects of a soy rich diet on the main biomarkers of cardiovascular health in menopause, compared with the effects of the hormone replacement therapy (HRT). Methods: 187 healthy asymptomatic postmenopausal women, aged 39-60, were recruited and randomized into three groups: a soy rich diet group, a HRT group, and a control group. Lipid profile, body mass index, blood pressure, endometrial thickness, uterine artery resistance index (RI), were evaluated in all the participants at the baseline, after 6 months, and at the end of the study. Results: After a 6-month intervention period, the lipid profile in the soy rich diet group showed a favourable outcome, similar to that observed in the HRT group, but compliance to the diet was low. Conclusion: Soy products may be used in the prevention of cardiovascular risk in postmenopausal women because of their efficacy in contrasting the negative effects of menopause on the cardiovascular system, but our findings should be confirmed; moreover, suitable strategies to improve the compliance have to be considered.
AB - Objective: To assess beneficial effects of a soy rich diet on the main biomarkers of cardiovascular health in menopause, compared with the effects of the hormone replacement therapy (HRT). Methods: 187 healthy asymptomatic postmenopausal women, aged 39-60, were recruited and randomized into three groups: a soy rich diet group, a HRT group, and a control group. Lipid profile, body mass index, blood pressure, endometrial thickness, uterine artery resistance index (RI), were evaluated in all the participants at the baseline, after 6 months, and at the end of the study. Results: After a 6-month intervention period, the lipid profile in the soy rich diet group showed a favourable outcome, similar to that observed in the HRT group, but compliance to the diet was low. Conclusion: Soy products may be used in the prevention of cardiovascular risk in postmenopausal women because of their efficacy in contrasting the negative effects of menopause on the cardiovascular system, but our findings should be confirmed; moreover, suitable strategies to improve the compliance have to be considered.
KW - Cardiovascular health
KW - Lipid profile
KW - Menopause
KW - Phytoestrogens
KW - Soy
UR - http://www.scopus.com/inward/record.url?scp=0037176790&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037176790&partnerID=8YFLogxK
U2 - 10.1016/S0378-5122(01)00259-6
DO - 10.1016/S0378-5122(01)00259-6
M3 - Article
C2 - 11836040
AN - SCOPUS:0037176790
SN - 0378-5122
VL - 41
SP - 97
EP - 104
JO - Maturitas
JF - Maturitas
IS - 2
ER -