The effect of selective lesioning of brain catecholamine-containing neurons on the activity of various anorectics in the rat

Rosario Samanin; Sergio Bernasconi; Silvio Garattini

doi:10.1016/0014-2999(75)90265-4

The effect of selective lesioning of brain catecholamine-containing neurons on the activity of various anorectics in the rat

Rosario Samanin, Sergio Bernasconi, Silvio Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

An intraventricular injection of 6-hydroxydopamine to rats pretreated with pargyline, a procedure which produces a marked decrease of brain catecholamines without significant changes in the serotonin levels, significantly antagonizes the anorectic effect of amphetamine, phentermine, mazindol and diethylpropion, while the reduction of food intake induced by other drugs such as fenfluramine, p-chloroamphetamine, SE 780 and SKF 1-39728 is not significantly affected. The data suggest and involvement of brain catecholamines in the anorectic effect of amphetamine, phentermine, mazindol and diethylpropion whereas other mechanisms appear to be involved in the activity of the other anorectics studied.

Original language	English
Pages (from-to)	373-375
Number of pages	3
Journal	European Journal of Pharmacology
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(75)90265-4
Publication status	Published - 1975

Keywords

Amphetamine
Anorexia
Brain catecholamines
Fenfluramine
Mazindol

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/0014-2999(75)90265-4

Cite this

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abstract = "An intraventricular injection of 6-hydroxydopamine to rats pretreated with pargyline, a procedure which produces a marked decrease of brain catecholamines without significant changes in the serotonin levels, significantly antagonizes the anorectic effect of amphetamine, phentermine, mazindol and diethylpropion, while the reduction of food intake induced by other drugs such as fenfluramine, p-chloroamphetamine, SE 780 and SKF 1-39728 is not significantly affected. The data suggest and involvement of brain catecholamines in the anorectic effect of amphetamine, phentermine, mazindol and diethylpropion whereas other mechanisms appear to be involved in the activity of the other anorectics studied.",

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AU - Bernasconi, Sergio

AU - Garattini, Silvio

PY - 1975

Y1 - 1975

N2 - An intraventricular injection of 6-hydroxydopamine to rats pretreated with pargyline, a procedure which produces a marked decrease of brain catecholamines without significant changes in the serotonin levels, significantly antagonizes the anorectic effect of amphetamine, phentermine, mazindol and diethylpropion, while the reduction of food intake induced by other drugs such as fenfluramine, p-chloroamphetamine, SE 780 and SKF 1-39728 is not significantly affected. The data suggest and involvement of brain catecholamines in the anorectic effect of amphetamine, phentermine, mazindol and diethylpropion whereas other mechanisms appear to be involved in the activity of the other anorectics studied.

AB - An intraventricular injection of 6-hydroxydopamine to rats pretreated with pargyline, a procedure which produces a marked decrease of brain catecholamines without significant changes in the serotonin levels, significantly antagonizes the anorectic effect of amphetamine, phentermine, mazindol and diethylpropion, while the reduction of food intake induced by other drugs such as fenfluramine, p-chloroamphetamine, SE 780 and SKF 1-39728 is not significantly affected. The data suggest and involvement of brain catecholamines in the anorectic effect of amphetamine, phentermine, mazindol and diethylpropion whereas other mechanisms appear to be involved in the activity of the other anorectics studied.

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KW - Anorexia

KW - Brain catecholamines

KW - Fenfluramine

KW - Mazindol

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The effect of selective lesioning of brain catecholamine-containing neurons on the activity of various anorectics in the rat

Abstract

Keywords

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