The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat

L. Manzo; R. Passoni; A. D. Segre; F. Bertè; A. Crema

doi:10.1007/BF01953115

The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat

L. Manzo, R. Passoni, A. D. Segre, F. Bertè, A. Crema

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

Oxine-5-sulphonic acid inhibits the metabolism of aminopyrine in the rat liver in vitro. The characteristics of this inhibition vary according to whether the oxidative N-demethylation of the substrate is determined by the formation of the metabolite 4-aminoantipyrine or by the production of formaldehyde.

Original language	English
Pages (from-to)	1318-1320
Number of pages	3
Journal	Experientia
Volume	32
Issue number	10
DOIs	https://doi.org/10.1007/BF01953115
Publication status	Published - Oct 1976

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/BF01953115

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title = "The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat",

abstract = "Oxine-5-sulphonic acid inhibits the metabolism of aminopyrine in the rat liver in vitro. The characteristics of this inhibition vary according to whether the oxidative N-demethylation of the substrate is determined by the formation of the metabolite 4-aminoantipyrine or by the production of formaldehyde.",

author = "L. Manzo and R. Passoni and Segre, {A. D.} and F. Bert{\`e} and A. Crema",

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AU - Crema, A.

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The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat

Abstract

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