TY - JOUR
T1 - The effect of opiate treatment on the postdecapitation reflex and monoamine metabolism in the rat spinal cord
AU - Plaznik, Adam
AU - de Simoni, Maria Grazia
AU - Algeri, Sergio
PY - 1983
Y1 - 1983
N2 - Postdecapitation seizures (PDR) are a spinal reflex which seems regulated by some monoaminergic neurons present in the spinal cord (S.C.). In order to better characterize the role of dopaminergic neurons in PDR, we studied the effect of treatment with opiates, which are known to increase dopamine (DA) and serotonin (5HT) metabolism in the brain, on the duration of PDR and on the metabolism of DA and 5HT in S.C. Morphine, given either IP or ICV, reduced the duration of PDR and increased DA metabolism. Both effects were more evident after systematic administration. [D-Ala2]Met5 enkephalin amide acted similarly to ICV administered morphine. Biochemical and behavioral effects were significantly correlated.
AB - Postdecapitation seizures (PDR) are a spinal reflex which seems regulated by some monoaminergic neurons present in the spinal cord (S.C.). In order to better characterize the role of dopaminergic neurons in PDR, we studied the effect of treatment with opiates, which are known to increase dopamine (DA) and serotonin (5HT) metabolism in the brain, on the duration of PDR and on the metabolism of DA and 5HT in S.C. Morphine, given either IP or ICV, reduced the duration of PDR and increased DA metabolism. Both effects were more evident after systematic administration. [D-Ala2]Met5 enkephalin amide acted similarly to ICV administered morphine. Biochemical and behavioral effects were significantly correlated.
KW - Dopamine
KW - Dopamine metabolism
KW - Postdecapitation reflex
KW - Spinal cord
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U2 - 10.1016/0091-3057(83)90114-4
DO - 10.1016/0091-3057(83)90114-4
M3 - Article
C2 - 6634893
AN - SCOPUS:0020532705
SN - 0091-3057
VL - 19
SP - 427
EP - 429
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 3
ER -