The E27 β2-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males

G. Sala; A. Di Castelnuovo; L. Cuomo; M. Gattone; P. Giannuzzi; L. Iacoviello; A. De Blasi

The E27 β₂-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males

G. Sala, A. Di Castelnuovo, L. Cuomo, M. Gattone, P. Giannuzzi, L. Iacoviello, A. De Blasi

Research output: Contribution to journal › Article › peer-review

Abstract

In the present study we evaluated whether two polymorphisms of β₂-adrenergic receptors (β₂-AR) gene (R16G and Q27E) could modify the risk of myocardial infarction (MI). Using a case-control design, we analyzed the data from 125 male patients who had experienced a first episode of MI before the age of 45 years and 108 male controls matched for age. The allele frequencies for R16G and Q27E were: G16=0.56 and E27=0.36 in patients with MI and G16=0.61 and E27=0.42 in the control group. There was a trend (not statistically significant) of decreasing MI risk according to E27 or G16 alleles. Combined effect between E27 allele and history of dyslipidemia has been observed. Whereas dyslipidemia conferred a relative risk of MI of 4.8 (P2-adrenergic receptor has a significant protective effect on MI in dyslipidemic young male.

Original language	English
Pages (from-to)	231-233
Number of pages	3
Journal	Thrombosis and Haemostasis
Volume	85
Issue number	2
Publication status	Published - 2001

Keywords

β-Adrenergic receptor polymorphisms
Dyslipidemia
Myocardial infarction

ASJC Scopus subject areas

Hematology

Cite this

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title = "The E27 β2-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males",

abstract = "In the present study we evaluated whether two polymorphisms of β2-adrenergic receptors (β2-AR) gene (R16G and Q27E) could modify the risk of myocardial infarction (MI). Using a case-control design, we analyzed the data from 125 male patients who had experienced a first episode of MI before the age of 45 years and 108 male controls matched for age. The allele frequencies for R16G and Q27E were: G16=0.56 and E27=0.36 in patients with MI and G16=0.61 and E27=0.42 in the control group. There was a trend (not statistically significant) of decreasing MI risk according to E27 or G16 alleles. Combined effect between E27 allele and history of dyslipidemia has been observed. Whereas dyslipidemia conferred a relative risk of MI of 4.8 (P2-adrenergic receptor has a significant protective effect on MI in dyslipidemic young male.",

keywords = "β-Adrenergic receptor polymorphisms, Dyslipidemia, Myocardial infarction",

author = "G. Sala and {Di Castelnuovo}, A. and L. Cuomo and M. Gattone and P. Giannuzzi and L. Iacoviello and {De Blasi}, A.",

year = "2001",

language = "English",

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journal = "Thrombosis and Haemostasis",

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T1 - The E27 β2-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males

AU - Sala, G.

AU - Di Castelnuovo, A.

AU - Cuomo, L.

AU - Gattone, M.

AU - Giannuzzi, P.

AU - Iacoviello, L.

AU - De Blasi, A.

PY - 2001

Y1 - 2001

N2 - In the present study we evaluated whether two polymorphisms of β2-adrenergic receptors (β2-AR) gene (R16G and Q27E) could modify the risk of myocardial infarction (MI). Using a case-control design, we analyzed the data from 125 male patients who had experienced a first episode of MI before the age of 45 years and 108 male controls matched for age. The allele frequencies for R16G and Q27E were: G16=0.56 and E27=0.36 in patients with MI and G16=0.61 and E27=0.42 in the control group. There was a trend (not statistically significant) of decreasing MI risk according to E27 or G16 alleles. Combined effect between E27 allele and history of dyslipidemia has been observed. Whereas dyslipidemia conferred a relative risk of MI of 4.8 (P2-adrenergic receptor has a significant protective effect on MI in dyslipidemic young male.

AB - In the present study we evaluated whether two polymorphisms of β2-adrenergic receptors (β2-AR) gene (R16G and Q27E) could modify the risk of myocardial infarction (MI). Using a case-control design, we analyzed the data from 125 male patients who had experienced a first episode of MI before the age of 45 years and 108 male controls matched for age. The allele frequencies for R16G and Q27E were: G16=0.56 and E27=0.36 in patients with MI and G16=0.61 and E27=0.42 in the control group. There was a trend (not statistically significant) of decreasing MI risk according to E27 or G16 alleles. Combined effect between E27 allele and history of dyslipidemia has been observed. Whereas dyslipidemia conferred a relative risk of MI of 4.8 (P2-adrenergic receptor has a significant protective effect on MI in dyslipidemic young male.

KW - β-Adrenergic receptor polymorphisms

KW - Dyslipidemia

KW - Myocardial infarction

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JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

IS - 2

ER -

The E27 β₂-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males

Abstract

Keywords

ASJC Scopus subject areas

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