The determinant factors of recurrence following resection for ductal pancreatic cancer

Giuliano Barugola, Massimo Falconi, Rossella Bettini, Letizia Boninsegna, Andrea Casarotto, Roberto Salvia, Claudio Bassi, Paolo Pederzoli

Research output: Contribution to journalArticlepeer-review


Long-term survival for patients with pancreatic carcinoma is low, even following resection. Most patients who undergo curative treatment, develop recurrence usually at the same site of resection or in the liver. Failure seals the fate of the patient. Local recurrence occurs frequently; however, it is rarely a direct cause of death. In fact, most patients die from distant metastases. From a clinical point of view, it is important to distinguish recurrence from relapse. In fact, recurrence can be recognized as the reappearance of the disease in the surgical bed, often due to inadequate surgical clearance. On the other hand, the concept of relapse should be much more related to the appearance of the disease in a distant site. Both underestimated staging of the diagnosis and the biological features of the tumor can cause relapse. Up to now, there have only been a few reviews on the incidence and pattern of failure following resection. Detailed knowledge of the recurring sites of pancreatic carcinoma and study of the factors influencing diseasefree survival are significant in developing neoadjuvant, surgical and adjuvant treatment. The aim of this review is to point out the major factors most commonly identified as determinants of both recurrence and relapse.

Original languageEnglish
Pages (from-to)132-140
Number of pages9
JournalJournal of the Pancreas
Issue number1 SUPPL
Publication statusPublished - 2007


  • Carcinoma
  • Operative
  • Pancreatic ductal
  • Pancreatic neoplasms
  • Recurrence
  • Surgical procedures

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Medicine(all)


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