The coexistence of type 1 diabetes, MODY2 and metabolic syndrome in a young girl

Valeria Calcaterra; Miryam Martinetti; Alessandro Salina; Concetta Aloi; Daniela Larizza

doi:10.1007/s00592-011-0300-2

The coexistence of type 1 diabetes, MODY2 and metabolic syndrome in a young girl

Valeria Calcaterra, Miryam Martinetti, Alessandro Salina, Concetta Aloi, Daniela Larizza

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Even though autoantibodies to pancreatic islet cells are normally found in type 1 diabetes and insulin-resistance due to overweight is more reminiscent of type 2 diabetes, some studies have described β-cell antibodies also in maturity-onset diabetes of the young (MODY) and in type 2 diabetes. A 7-year-old girl was referred to our Unit for incidental hyperglycemia and family history of MODY2 and type 2 diabetes. Genetic evaluation confirmed mutation L134P in exon 4 of the glucokinase gene and a high HLA-risk of type 1 diabetes. During follow-up, she developed type 1 diabetes and overweight-induced metabolic syndrome. The coexistence of MODY, type 1 diabetes and overweight-induced metabolic syndrome confirms that diabetes subtype probably represents a continuum of immune and metabolic dysfunction modified by genetic factors.

Original language	English
Pages (from-to)	401-404
Number of pages	4
Journal	Acta Diabetologica
Volume	49
Issue number	5
DOIs	https://doi.org/10.1007/s00592-011-0300-2
Publication status	Published - Oct 2012

Keywords

Metabolic syndrome
MODY2
Type 1 diabetes

ASJC Scopus subject areas

Endocrinology
Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.1007/s00592-011-0300-2

Cite this

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abstract = "Even though autoantibodies to pancreatic islet cells are normally found in type 1 diabetes and insulin-resistance due to overweight is more reminiscent of type 2 diabetes, some studies have described β-cell antibodies also in maturity-onset diabetes of the young (MODY) and in type 2 diabetes. A 7-year-old girl was referred to our Unit for incidental hyperglycemia and family history of MODY2 and type 2 diabetes. Genetic evaluation confirmed mutation L134P in exon 4 of the glucokinase gene and a high HLA-risk of type 1 diabetes. During follow-up, she developed type 1 diabetes and overweight-induced metabolic syndrome. The coexistence of MODY, type 1 diabetes and overweight-induced metabolic syndrome confirms that diabetes subtype probably represents a continuum of immune and metabolic dysfunction modified by genetic factors.",

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AU - Martinetti, Miryam

AU - Salina, Alessandro

AU - Aloi, Concetta

AU - Larizza, Daniela

PY - 2012/10

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The coexistence of type 1 diabetes, MODY2 and metabolic syndrome in a young girl

Abstract

Keywords

ASJC Scopus subject areas

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