The chromosome 9 ALS and FTD locus is probably derived from a single founder

Kin Mok; Bryan J. Traynor; Jennifer Schymick; Pentti J. Tienari; Hannu Laaksovirta; Terhi Peuralinna; Liisa Myllykangas; Adriano Chiò; Aleksey Shatunov; Bradley F. Boeve; Adam L. Boxer; Mariely DeJesus-Hernandez; Ian R. Mackenzie; Adrian Waite; Nigel Williams; Huw R. Morris; Javier Simón-Sánchez; John C. van Swieten; Peter Heutink; Gabriella Restagno; Gabriele Mora; Karen E. Morrison; Pamela J. Shaw; Pamela Sara Rollinson; Ammar Al-Chalabi; Rosa Rademakers; Stuart Pickering-Brown; Richard W. Orrell; Michael A. Nalls; John Hardy

doi:10.1016/j.neurobiolaging.2011.08.005

The chromosome 9 ALS and FTD locus is probably derived from a single founder

Kin Mok, Bryan J. Traynor, Jennifer Schymick, Pentti J. Tienari, Hannu Laaksovirta, Terhi Peuralinna, Liisa Myllykangas, Adriano Chiò, Aleksey Shatunov, Bradley F. Boeve, Adam L. Boxer, Mariely DeJesus-Hernandez, Ian R. Mackenzie, Adrian Waite, Nigel Williams, Huw R. Morris, Javier Simón-Sánchez, John C. van Swieten, Peter Heutink, Gabriella RestagnoGabriele Mora, Karen E. Morrison, Pamela J. Shaw, Pamela Sara Rollinson, Ammar Al-Chalabi, Rosa Rademakers, Stuart Pickering-Brown, Richard W. Orrell, Michael A. Nalls, John Hardy

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.

Original language	English
Journal	Neurobiology of Aging
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2011.08.005
Publication status	Published - Jan 2012

Keywords

Amyotrophic lateral sclerosis
Finland
Frontotemporal dementia
Genetics

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)
Ageing
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2011.08.005

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Mok, K., Traynor, B. J., Schymick, J., Tienari, P. J., Laaksovirta, H., Peuralinna, T., Myllykangas, L., Chiò, A., Shatunov, A., Boeve, B. F., Boxer, A. L., DeJesus-Hernandez, M., Mackenzie, I. R., Waite, A., Williams, N., Morris, H. R., Simón-Sánchez, J., van Swieten, J. C., Heutink, P., ... Hardy, J. (2012). The chromosome 9 ALS and FTD locus is probably derived from a single founder. Neurobiology of Aging, 33(1). https://doi.org/10.1016/j.neurobiolaging.2011.08.005

Mok, K, Traynor, BJ, Schymick, J, Tienari, PJ, Laaksovirta, H, Peuralinna, T, Myllykangas, L, Chiò, A, Shatunov, A, Boeve, BF, Boxer, AL, DeJesus-Hernandez, M, Mackenzie, IR, Waite, A, Williams, N, Morris, HR, Simón-Sánchez, J, van Swieten, JC, Heutink, P, Restagno, G, Mora, G, Morrison, KE, Shaw, PJ, Rollinson, PS, Al-Chalabi, A, Rademakers, R, Pickering-Brown, S, Orrell, RW, Nalls, MA & Hardy, J 2012, 'The chromosome 9 ALS and FTD locus is probably derived from a single founder', Neurobiology of Aging, vol. 33, no. 1. https://doi.org/10.1016/j.neurobiolaging.2011.08.005

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title = "The chromosome 9 ALS and FTD locus is probably derived from a single founder",

abstract = "We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.",

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AU - Traynor, Bryan J.

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AU - Tienari, Pentti J.

AU - Laaksovirta, Hannu

AU - Peuralinna, Terhi

AU - Myllykangas, Liisa

AU - Chiò, Adriano

AU - Shatunov, Aleksey

AU - Boeve, Bradley F.

AU - Boxer, Adam L.

AU - DeJesus-Hernandez, Mariely

AU - Mackenzie, Ian R.

AU - Waite, Adrian

AU - Williams, Nigel

AU - Morris, Huw R.

AU - Simón-Sánchez, Javier

AU - van Swieten, John C.

AU - Heutink, Peter

AU - Restagno, Gabriella

AU - Mora, Gabriele

AU - Morrison, Karen E.

AU - Shaw, Pamela J.

AU - Rollinson, Pamela Sara

AU - Al-Chalabi, Ammar

AU - Rademakers, Rosa

AU - Pickering-Brown, Stuart

AU - Orrell, Richard W.

AU - Nalls, Michael A.

AU - Hardy, John

PY - 2012/1

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AB - We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.

KW - Amyotrophic lateral sclerosis

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KW - Frontotemporal dementia

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The chromosome 9 ALS and FTD locus is probably derived from a single founder

Abstract

Keywords

ASJC Scopus subject areas

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