The autonomic nervous system and cardiovascular disease: Role of n-3 PUFAs

Maria Teresa La Rovere, Jeppe Hagstrup Christensen

Research output: Contribution to journalArticlepeer-review


In the last decades, a large body of experimental and clinical evidence has been accumulated showing that cardiovascular diseases are often accompanied by an imbalance in the sympathetic-vagal outflow to the heart, resulting in a chronic adrenergic activation. The arterial baroreceptor system is a key component of mechanisms contributing to the neural regulation of the cardiovascular system. Several methods have been proposed to assess autonomic activity by analyzing heart rate and blood pressure changes either spontaneously occurring or following provocations. The autonomic nervous system has been regarded as one of the putative mechanisms involved into the beneficial effects of exposure to n-3 fatty acids observed in epidemiological studies. The aim of the present review is to provide an update on the clinical evidence proposed so far linking exposure to n-3 fatty acids to autonomic nervous system modulation.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalVascular Pharmacology
Publication statusPublished - Aug 1 2015


  • Autonomic nervous system
  • Baroreflex sensitivity
  • Cardiovascular disease
  • Heart rate variability
  • N-3 PUFA

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine
  • Physiology


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