The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer

Thomas Scattolin; Enrica Bortolamiol; Stefano Palazzolo; Isabella Caligiuri; Tiziana Perin; Vincenzo Canzonieri; Nicola Demitri; Flavio Rizzolio; Luigi Cavallo; Busra Dereli; Manoj V. Mane; Steven P. Nolan; Fabiano Visentin

doi:10.1039/d0cc03883k

The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer

Thomas Scattolin, Enrica Bortolamiol, Stefano Palazzolo, Isabella Caligiuri, Tiziana Perin, Vincenzo Canzonieri, Nicola Demitri, Flavio Rizzolio, Luigi Cavallo, Busra Dereli, Manoj V. Mane, Steven P. Nolan, Fabiano Visentin

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.

Original language	English
Pages (from-to)	12238-12241
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	81
DOIs	https://doi.org/10.1039/d0cc03883k
Publication status	Published - Oct 18 2020

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer",

abstract = "A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.",

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doi = "10.1039/d0cc03883k",

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T1 - The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer

AU - Scattolin, Thomas

AU - Bortolamiol, Enrica

AU - Palazzolo, Stefano

AU - Caligiuri, Isabella

AU - Perin, Tiziana

AU - Canzonieri, Vincenzo

AU - Demitri, Nicola

AU - Rizzolio, Flavio

AU - Cavallo, Luigi

AU - Dereli, Busra

AU - Mane, Manoj V.

AU - Nolan, Steven P.

AU - Visentin, Fabiano

PY - 2020/10/18

Y1 - 2020/10/18

N2 - A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.

AB - A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer

Abstract

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