The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer

Thomas Scattolin, Enrica Bortolamiol, Stefano Palazzolo, Isabella Caligiuri, Tiziana Perin, Vincenzo Canzonieri, Nicola Demitri, Flavio Rizzolio, Luigi Cavallo, Busra Dereli, Manoj V. Mane, Steven P. Nolan, Fabiano Visentin

Research output: Contribution to journalArticlepeer-review


A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.

Original languageEnglish
Pages (from-to)12238-12241
Number of pages4
JournalChemical Communications
Issue number81
Publication statusPublished - Oct 18 2020

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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