The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment

Sanne K. Meles; Marco Pagani; Dario Arnaldi; Fabrizio De Carli; Barbara Dessi; Silvia Morbelli; Gianmario Sambuceti; Cathrine Jonsson; Klaus L. Leenders; Flavio Nobili

doi:10.1177/0271678X17732508

The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment

Sanne K. Meles, Marco Pagani, Dario Arnaldi, Fabrizio De Carli, Barbara Dessi, Silvia Morbelli, Gianmario Sambuceti, Cathrine Jonsson, Klaus L. Leenders, Flavio Nobili

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the expression of the Alzheimer’s disease-related metabolic brain pattern (ADRP) in ¹⁸F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer’s disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%). Assessment of ¹⁸F-FDG-PET scans on a case-by-case basis using the ADRP may be useful for quantifying disease progression.

Original language	English
Pages (from-to)	3643-3648
Number of pages	6
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	37
Issue number	12
DOIs	https://doi.org/10.1177/0271678X17732508
Publication status	Published - Dec 1 2017

Keywords

F-FDG-PET
Alzheimer’s disease
mild cognitive impairment
normal aging
principal component analysis

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1177/0271678X17732508

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title = "The Alzheimer{\textquoteright}s disease metabolic brain pattern in mild cognitive impairment",

abstract = "We investigated the expression of the Alzheimer{\textquoteright}s disease-related metabolic brain pattern (ADRP) in 18F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer{\textquoteright}s disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%). Assessment of 18F-FDG-PET scans on a case-by-case basis using the ADRP may be useful for quantifying disease progression.",

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AU - Meles, Sanne K.

AU - Pagani, Marco

AU - Arnaldi, Dario

AU - De Carli, Fabrizio

AU - Dessi, Barbara

AU - Morbelli, Silvia

AU - Sambuceti, Gianmario

AU - Jonsson, Cathrine

AU - Leenders, Klaus L.

AU - Nobili, Flavio

PY - 2017/12/1

Y1 - 2017/12/1

N2 - We investigated the expression of the Alzheimer’s disease-related metabolic brain pattern (ADRP) in 18F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer’s disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%). Assessment of 18F-FDG-PET scans on a case-by-case basis using the ADRP may be useful for quantifying disease progression.

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KW - F-FDG-PET

KW - Alzheimer’s disease

KW - mild cognitive impairment

KW - normal aging

KW - principal component analysis

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The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment

Abstract

Keywords

ASJC Scopus subject areas

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