The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors

Matteo Bellone; Arianna Calcinotto; Paola Filipazzi; Angelo De Milito; Stefano Fais; Licia Rivoltini

doi:10.4161/onci.22058

The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors

Matteo Bellone, Arianna Calcinotto, Paola Filipazzi, Angelo De Milito, Stefano Fais, Licia Rivoltini

Research output: Contribution to journal › Article › peer-review

Abstract

We have recently reported that lowering the pH to values that are frequently detected in tumors causes reversible anergy in both human and mouse CD8⁺ T lymphocytes in vitro. The same occurs in vivo, in the tumor microenvironment and the administration of proton pump inhibitors, which buffer tumor acidity, can revert T-cell anergy and increase the efficacy of immunotherapy.

Original language	English
Article number	e22058
Journal	OncoImmunology
Volume	2
Issue number	1
DOIs	https://doi.org/10.4161/onci.22058
Publication status	Published - Jan 2013

Keywords

Active immunotherapy
Adoptive immunotherapy
Anergy
Melanoma
Prostate cancer
T cell

ASJC Scopus subject areas

Immunology and Allergy
Oncology
Immunology

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10.4161/onci.22058

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AU - Fais, Stefano

AU - Rivoltini, Licia

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The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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